Status:
WITHDRAWN
Glutamine Enriched Total Parenteral Feeding and Proline Metabolism in Severely Burned Patients
Lead Sponsor:
Massachusetts General Hospital
Collaborating Sponsors:
National Institutes of Health (NIH)
Conditions:
Burns
Eligibility:
All Genders
18+ years
Brief Summary
Proline is a non-essential amino acid that helps with collagen formation. Collagen is one of the main ingredients of skin, bone, tendons, and connective tissue. It is thought that proline becomes depl...
Detailed Description
Proline is a nutritionally dispensable (non-essential) amino acid. Its synthesis and catabolism is via the pathway of ornithine and glutamate. The latter two amino acids serve as immediate precursors ...
Eligibility Criteria
Inclusion
- Burn patients being treated at MGH Burn Unit with one or more of the following criteria: 1) \>=5% TBSA; 2) inhalation injury; or 3) resting energy expenditure (REE) of \>15% of the predicted Basal Metabolic Rate using the Harris-Benedict equation.
- Must be receiving total parenteral nutrition in the course of their treatment.
Exclusion
- Patients with thyroid disease. Patients who are not hemodynamically stable or show unstable vital signs Patients at the stage of major organ failure, e.g. renal and/or liver failure.
Key Trial Info
Start Date :
August 1 1997
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
January 1 2010
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT00217035
Start Date
August 1 1997
End Date
January 1 2010
Last Update
January 13 2017
Active Locations (1)
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1
Massachusetts General Hospital Burn Unit
Boston, Massachusetts, United States, 02114