Status:
COMPLETED
Treatment of Malaria in Gabon With Fosmidomycin-Clindamycin
Lead Sponsor:
Albert Schweitzer Hospital
Conditions:
Malaria
Eligibility:
All Genders
12-14 years
Phase:
PHASE2
Brief Summary
Some antibiotics are also effective against malaria parasites. Fosmidomycin is an antibiotic that has been shown to be effective against malaria, although it cannot achieve a total cure in all patient...
Detailed Description
The treatment of malaria is becoming increasingly difficult due to the development of Plasmodium falciparum strains resistant to commonly used antimalarials. Fosmidomycin was shown to be well tolerate...
Eligibility Criteria
Inclusion
- Uncomplicated P. falciparum malaria with acute manifestation
- Asexual parasitemia between 1,000-100,000/μL
- Body weight between 5-65 kg
- Ability to tolerate oral therapy
- Informed consent, oral agreement of the child if appropriate
- Residence in the study area for the duration of at least 4 weeks
Exclusion
- Adequate anti-malarial treatment within the previous 7 days
- Antibiotic treatment for a concurrent infection
- Haemoglobin \<7g/dL
- Hematocrit \<25%
- Leukocyte count \>15,000/μL
- Mixed plasmodial infection
- Severe malaria, any other severe underlying disease
- Concomitant disease masking assessment of treatment response
- Inflammatory bowel disease, and any other disease causing fever.
Key Trial Info
Start Date :
June 1 2002
Trial Type :
INTERVENTIONAL
End Date :
March 1 2003
Estimated Enrollment :
51 Patients enrolled
Trial Details
Trial ID
NCT00217451
Start Date
June 1 2002
End Date
March 1 2003
Last Update
September 22 2005
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Medical Research Unit, Lambaréné
Lambaréné, Moyen-Ogooué Province, Gabon, B.P. 118