Status:
COMPLETED
Pathogen Specific Immunity in Patients With Sarcoidosis
Lead Sponsor:
University of Medicine and Dentistry of New Jersey
Collaborating Sponsors:
National Heart, Lung, and Blood Institute (NHLBI)
Conditions:
Sarcoidosis
Eligibility:
All Genders
18-65 years
Brief Summary
The purpose of this study is to assess the lung cells of healthy volunteers and patients with stage II and III pulmonary sarcoidosis for pathogen specific memory immunity and gene expression patterns.
Detailed Description
BACKGROUND: Since its initial description 125 years ago, sarcoidosis continues to be a "challenging" disease. Its etiology remains unknown. Discovering the etiology of sarcoidosis remains a major goa...
Eligibility Criteria
Inclusion
- Inclusion Criteria for Sarcoidosis Participants:
- Clinical and radiographic signs and symptoms consistent with pulmonary sarcoidosis stage II or III and confirmed histopathology
- No prior corticosteroid or immune suppressive or immune modulating therapies
- Inclusion Criteria for Healthy Participants:
- No clinical and radiographic signs and symptoms of respiratory or other chronic or systemic illness
- Exclusion Criteria for All Participants:
- Unwilling or unable to provide informed consent
- Unwilling or unable to comply with all study requirements
- History of upper or lower respiratory tract infection within 1 month of study entry
- History of major occupational or microbial exposures known to be associated with granulomatous inflammatory responses
- Positive HIV-1 serology
- Severe psychiatric disease
- Cough-induced syncope
- History of massive hemoptysis or history of pneumothorax, tuberculosis, and immunosuppressive therapies
- Presence of any chronic medical condition requiring daily medication
- Gingivitis or other infectious processes in the oral cavity
- Positive skin test to purified protein derivative (tuberculin)
- Hemoglobin level less than 10g/dl
- Illicit drug use or history of cigarette smoking within 1 year prior to study entry
Exclusion
Key Trial Info
Start Date :
July 1 2004
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
June 1 2008
Estimated Enrollment :
5 Patients enrolled
Trial Details
Trial ID
NCT00217789
Start Date
July 1 2004
End Date
June 1 2008
Last Update
December 24 2013
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
University of Medicine and Dentistry of New Jersey
Newark, New Jersey, United States, 07103