Status:
COMPLETED
Effectiveness of GABA Agonists in Reducing the Reinforcing Effects of Cocaine
Lead Sponsor:
National Institute on Drug Abuse (NIDA)
Conditions:
Cocaine-Related Disorders
Eligibility:
All Genders
18-50 years
Phase:
PHASE2
Brief Summary
Cocaine abuse continues to represent a significant public-health concern. Cocaine likely creates its addictive effects by increasing levels of dopamine, a chemical found in the brain. GABA agonists ar...
Detailed Description
Cocaine likely creates its reinforcing and addictive effects by increasing levels of dopamine, a brain neurotransmitter. GABA agonists are chemicals that have the opposite effect by inhibiting the rel...
Eligibility Criteria
Inclusion
- Recent use of cocaine
- Meets DSM-IV diagnostic criteria for psychoactive substance abuse or dependence for cocaine
- Positive drug urine screen for cocaine at time of initial screening interview
- Reports self-administration of at least 1,260 mg of cocaine during the 4 weeks prior to study start date
- Body Mass Index (BMI) of less than 29
- Females must use an effective form of contraception throughout the study
Exclusion
- Meets DSM-IV diagnostic criteria for psychoactive substance dependence for substances other than cocaine or nicotine
- Currently seeking treatment for substance abuse/dependence
- Current or past history of physical disease, impaired cardiovascular functioning, chronic obstructive pulmonary disease
- History of seizure, head traumas, or central nervous system tumors
- Current or past history of serious psychiatric disorder other than substance abuse or dependence
- Family history of cardiovascular disease or seizure disorders
Key Trial Info
Start Date :
August 1 2001
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 1 2005
Estimated Enrollment :
78 Patients enrolled
Trial Details
Trial ID
NCT00218166
Start Date
August 1 2001
End Date
May 1 2005
Last Update
January 11 2017
Active Locations (1)
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1
University of Kentucky Medical Center
Lexington, Kentucky, United States, 40536 0086