Status:
COMPLETED
Disulfiram for Treating Cocaine Dependence in Individuals Maintained on Methadone
Lead Sponsor:
University of Arkansas
Collaborating Sponsors:
Yale University
Conditions:
Cocaine-Related Disorders
Opioid-Related Disorders
Eligibility:
All Genders
18-65 years
Phase:
PHASE2
Brief Summary
Cocaine is an extremely addictive stimulant drug that directly affects the brain. It is used in several different forms and can be snorted, smoked, or injected to achieve the desired effect. Cocaine u...
Detailed Description
Despite the harm that cocaine can cause to the body, its abuse is widespread. It is the cause of more visits to hospital emergency rooms nationwide than any other illegal drug. Effective treatments fo...
Eligibility Criteria
Inclusion
- History of cocaine use at least once a week during the month prior to study entry
- Urine screen tests positive for cocaine
- Meets DSM-IV criteria for opioid- and cocaine-dependence
- Urine toxicology screen tests negative for benzodiazepines prior to beginning methadone treatment
Exclusion
- Current drug or alcohol dependence other than opiates, cocaine, or tobacco
- Significant medical condition, such as abnormal liver function (with laboratory findings greater than three times normal), active hepatitis, or high blood pressure
- Current cardiac condition
- Occult coronary artery disease
- At high risk for cardiovascular disease, seizure disorders, or any other significant underlying medical condition that may make treatment with disulfiram or methadone unsafe
- Meets DSM-IV psychiatric diagnostic criteria for lifetime schizophrenia, bipolar disorder, or other psychotic disorders
- Currently suicidal or homicidal
- Currently taking a prescribed psychotropic medication that cannot be discontinued
- Pregnant
- Currently taking metronidazole or clotrimazole
Key Trial Info
Start Date :
April 1 2001
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 1 2007
Estimated Enrollment :
158 Patients enrolled
Trial Details
Trial ID
NCT00218608
Start Date
April 1 2001
End Date
January 1 2007
Last Update
January 31 2012
Active Locations (1)
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1
University of Arkansas for Medical Sciences
Little Rock, Arkansas, United States, 72205 7911