Status:
COMPLETED
Role of Esophageal Mast Cell Activation in Noncardiac Chest Pain (NCCP)
Lead Sponsor:
Milton S. Hershey Medical Center
Conditions:
Noncardiac Chest Pain (NCCP)
Eligibility:
All Genders
18-70 years
Brief Summary
Chest pain is a common clinical complaint. About 30% patients with chest pain will have a normal coronary angiogram and are described as having noncardiac chest pain (NCCP). It is estimated that 25% o...
Detailed Description
1. Key Objectives: To determine the density and activation of esophageal mast cells in non-cardiac chest pain patients. We expect to find mast cell activation, as measured by mast cell count or degran...
Eligibility Criteria
Inclusion
- NCCP - presence of a history of chest pain with a negative cardiac evaluation, no evidence of gross esophagitis on endoscopy, and lack of any exclusion criteria; Reflux esophagitis - presence of chest pain or heartburn, negative cardiac evaluation, lack of exclusion criteria and presence of esophagitis on endoscopy;
- Controls - lack of history of chest pain, lack of exclusion criteria and lack of esophagitis on endoscopy. It is anticipated that patients being evaluated for heme positive stool or GI bleeding would be included as controls.
Exclusion
- \- History of ischemic heart disease, history of asthma, significant food allergies, celiac disease, chronic inflammatory conditions (SLE, rheumatoid arthritis), atopic skin disease, varices, coagulopathy, recent drug treatment with steroids.
Key Trial Info
Start Date :
September 1 2005
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
August 21 2014
Estimated Enrollment :
86 Patients enrolled
Trial Details
Trial ID
NCT00219492
Start Date
September 1 2005
End Date
August 21 2014
Last Update
June 20 2017
Active Locations (1)
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1
Penn State College of Medicine Hershey Medical Center
Hershey, Pennsylvania, United States, 17033