Status:
COMPLETED
Effects of Propofol on Oxidative Stress and Liver Regeneration After Partial Hepatectomy
Lead Sponsor:
Rennes University Hospital
Collaborating Sponsors:
Ministry of Health, France
Conditions:
Hepatectomy
Eligibility:
All Genders
18+ years
Phase:
PHASE3
Brief Summary
Propofol is an anaesthetic agent that showed in vitro and in vivo anti oxidant properties. No data are available concerning the potential benefit of a total anaesthesia with propofol in partial hepati...
Detailed Description
Propofol is an anaesthetic agent that showed in vitro and in vivo anti oxidant properties. No data are available concerning the potential benefit of a total anaesthesia with propofol in partial hepati...
Eligibility Criteria
Inclusion
- Inclusion Criteria:
- Patients over 18
- Need for partial hepatic resection requiring heptic clamping
- Resection of 4 liver segments or less
- In case of cirrhosis, child A
- Written informed consent
- Non-inclusion Criteria:
- Hemochromatosis
- chemotherapy in the previous week before inclusion
- Thrombosis of the portal vein or the hepatic artery
- Absence of contraception among fertil woman
- Concomitant treatment that could have potential interaction with propofol
- Concomitant treatment known to have antioxidant properties
- Inclusion in another study protocol using a medication incompatible with the present study
- Patient in which the follow up seems impossible
Exclusion
Key Trial Info
Start Date :
August 1 2004
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 1 2006
Estimated Enrollment :
34 Patients enrolled
Trial Details
Trial ID
NCT00219856
Start Date
August 1 2004
End Date
March 1 2006
Last Update
June 26 2012
Active Locations (1)
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1
Surgical Intensive Care Unit - Rennes University Hospital
Rennes, France, 35033