Status:
COMPLETED
Cognitive Effects of Aerobic Exercise for IGT Adults
Lead Sponsor:
Seattle Institute for Biomedical and Clinical Research
Collaborating Sponsors:
American Diabetes Association
Conditions:
Impaired Glucose Tolerance
Eligibility:
All Genders
55-90 years
Phase:
PHASE2
Brief Summary
The specific aims for the study will be to determine if aerobic exercise enhances cognition for older adults who are at risk for developing type II diabetes mellitus (T2DM), and to evaluate whether ch...
Detailed Description
The benefits of exercise on cognition have been demonstrated both in animals and humans. Exercise has salutary effects on glucoregulation and visceral adiposity, an important link for adults with impa...
Eligibility Criteria
Inclusion
- diagnosed with IGT using OGTT, at least 55 years old, sedentary (elevated HR \& SOB \< 3x/wk for \<30min each occasion), good overall health, willing to exercise at least 4 days/week for 6 mos
Exclusion
- Significant neurologic disease that might affect cognition, such as AD, stroke, Parkinson's disease, multiple sclerosis, or severe head injury with loss of consciousness; significant medical illness or organ failure, such as liver disease, significant elevations in liver function tests, kidney disease, and uncontrolled hypertension (BP \> 140/90 on medication); cardiovascular disease defined as any acute cardiovascular abnormality, such as new or unstable angina, uncontrolled irregular heart beat (treated a-fib and occasional PVC's are OK) or symptomatic heart failure, acute shortness of breath for any reason, or clinically significant edema; chronic lung disease, (COPD/emphysema); musculoskeletal impairment (impaired walking); current use of anti-psychotic, anti-convulsant, anti-coagulant, sedative medication, or cognition-enhancing medications; current or previous use of hypoglycemic agents or insulin.
Key Trial Info
Start Date :
July 1 2004
Trial Type :
INTERVENTIONAL
End Date :
April 1 2008
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT00220441
Start Date
July 1 2004
End Date
April 1 2008
Last Update
July 30 2008
Active Locations (2)
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1
Veterans Affairs Puget Sound Health Care System
Seattle, Washington, United States, 98108
2
Veterans Affairs Puget Sound Health Care System
Tacoma, Washington, United States, 98493