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Status:

WITHDRAWN

Can Additional Drug Therapy Accelerate Response Time to Antidepressants

Lead Sponsor:

Mark Frye

Collaborating Sponsors:

University of California, Los Angeles

Conditions:

Depression

Eligibility:

All Genders

18-65 years

Phase:

PHASE4

Brief Summary

Antidepressants are commonly prescribed and are effective for treating depression. However, they generally take 4-6 weeks for a therapeutic response. This study is evaluating whether simultaneous trea...

Detailed Description

Major depression is an illness with substantial personal and economic morbidity (Greenberg et al.1993) and antidepressants are the cornerstone of treatment. As antidepressants usually require 3-6 week...

Eligibility Criteria

Inclusion

  • Patients, male and female, between the ages of 18 to 65
  • DSM-IV criteria for major depressive disorder
  • No prior SSRI medication treatment (if a patient has discontinued a non-SSRI medication for side effects, they will not be excluded)
  • Ability to be followed clinically for 6 weeks
  • Each patient must understand the nature of the study and must sign an informed consent form

Exclusion

  • Severe suicidality (as defined by Beck Depression Inventory Question 9, responses 2 or 3)
  • Major Axis I mental illness other than major depressive disorder
  • Unstable medical health specifically cardiovascular disease, abnormal EKG, history of severe drug allergy, poorly controlled diabetes, and asthma (pindolol contraindication)
  • History of thyroid disease or abnormal TFT's (stage I or II)
  • Need for adjunctive antipsychotic use or additional benzodiazepine during the study
  • Pregnancy
  • Seizure disorder
  • A positive urine toxicology screen

Key Trial Info

Start Date :

January 1 2004

Trial Type :

INTERVENTIONAL

Allocation :

ACTUAL

End Date :

Estimated Enrollment :

Patients enrolled

Trial Details

Trial ID

NCT00221494

Start Date

January 1 2004

Last Update

June 1 2015

Active Locations (1)

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UCLA Neuropsychiatric Institute

Los Angeles, California, United States, 90095