Status:
COMPLETED
Adjunctive Treatment for Decreasing Symptoms of Schizophrenia
Lead Sponsor:
University of Maryland, Baltimore
Collaborating Sponsors:
National Institute of Mental Health (NIMH)
The Zucker Hillside Hospital
Conditions:
Schizophrenia
Schizoaffective Disorder
Eligibility:
All Genders
18-54 years
Phase:
PHASE2
PHASE3
Brief Summary
This study will determine the effectiveness of treatment with glycine or d-cycloserine in addition to a normal antipsychotic regimen in improving negative symptoms and cognitive impairments in patient...
Detailed Description
A double-blind, placebo controlled clinical trial to examine whether adjunctive treatment with glycine or d-cycloserine, compared to placebo, will improve negative symptoms and cognitive impairments i...
Eligibility Criteria
Inclusion
- diagnosis of schizophrenia or schizoaffective disorder
- stable, enduring negative symptoms above a certain level (SANS \>19)
- clinically stable, with psychotic symptoms measured on BPRS below 19, anxiety/depression on BPRS below 15
- extrapyramidal symptoms measured on SAS below 9
- on stable antipsychotic regimen (not including clozapine)
Exclusion
- alcohol or substance dependence within last six months
- alcohol or substance abuse within last month
- organic brain disorder
- medical condition whose pathology or treatment could alter the presentation or treatment of schizophrenia, including active tuberculosis or tuberculosis treatment, kidney stones, and uncontrolled diabetes mellitus
- Female participants could not be pregnant and were required to be using a documented method of contraception.
Key Trial Info
Start Date :
January 1 2000
Trial Type :
INTERVENTIONAL
End Date :
June 1 2004
Estimated Enrollment :
240 Patients enrolled
Trial Details
Trial ID
NCT00222235
Start Date
January 1 2000
End Date
June 1 2004
Last Update
August 20 2019
Active Locations (5)
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1
UCLA/VA Greater Los Angeles Health Care System
Los Angeles, California, United States, 90073
2
Maryland Psychiatric Research Center
Baltimore, Maryland, United States, 21228
3
Zucker Hillside Hospital
Glen Oaks, New York, United States, 11004
4
Nathan S Kline Institute for Psychiatric Research
Orangeburg, New York, United States, 10982