Status:
COMPLETED
A Comparative Study of New Medications for Psychosis in Adolescents
Lead Sponsor:
University of Minnesota
Collaborating Sponsors:
AstraZeneca
Jensen, Jonathan B., M.D.
Conditions:
Psychotic Disorders
Schizophrenia
Eligibility:
All Genders
12-18 years
Phase:
NA
Brief Summary
The overall goal of this study is to determine the efficacy and tolerability of three atypical antipsychotic medications (risperidone, olanzapine, and quetiapine) in the treatment of adolescents with ...
Detailed Description
The purpose of this study is to compare the efficacy and tolerance of three atypical antipsychotics, which are medications that have been in use for about the last 10 years, in the treatment of psycho...
Eligibility Criteria
Inclusion
- Subjects are between the ages of 12-18 and have a diagnosis of a psychotic illness.
- Subject currently meets criteria for one of the following disorders: schizophrenia, schizoaffective disorder (mainly schizophrenic), schizophreniform disorder, and psychosis NOS.
- Subject is in good physical health and not suffering from any medical disorder that might mimic psychosis or lead to medical difficulty with the study medications.
- If subject is taking antipsychotic medication before study entry, their medicine will be discontinued for 1-4 days depending on symptoms.
Exclusion
- Subject has a medical disorders that would interfere with the study, such as epilepsy, thyroid disease, liver disease, AIDS, etc.
- Subject currently has substance dependence.
- Subject is talking a medication that inhibits or induces the cytochrome P450 3A4 (specific medications listed in Appendix of protocol).
- 3\. Subject meets criteria for brief psychosis or mood disorder with psychotic features.
- 4\. Female subject is pregnant or nursing.
Key Trial Info
Start Date :
August 1 2002
Trial Type :
INTERVENTIONAL
End Date :
August 1 2006
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT00222495
Start Date
August 1 2002
End Date
August 1 2006
Last Update
September 11 2006
Active Locations (1)
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1
University of Minnesota Medical Center
Minneapolis, Minnesota, United States, 55454