Status:
COMPLETED
Depression: The Search for Treatment-Relevant Phenotypes-Pilot Study
Lead Sponsor:
University of Pittsburgh
Collaborating Sponsors:
Mental Health Intervention Research Center (MHIRC)
Conditions:
Major Depression
Eligibility:
All Genders
18-65 years
Phase:
PHASE4
Brief Summary
We are doing this pilot study to learn more about four aspects of treating depression: 1. The features of a depressed person's mood and anxiety and how these features affect a person's capacity to ge...
Detailed Description
This pilot study is an experimental investigation designed so that consenting subjects are randomly assigned to pharmacotherapeutic or psychotherapeutic interventions for depression. For the initial ...
Eligibility Criteria
Inclusion
- 1\. Men and women 2 Age 18-65 3. Currently experiencing an episode of major depression 4. Not currently receiving effective treatment 5. Females of childbearing potential: practicing an acceptable form of birth control 6. Subjects with suicidal ideation are eligible as long as outpatient treatment is deemed safe 7. Willingness and ability to give informed consent.
Exclusion
- History of manic or hypomanic episodes;
- History of schizophrenia or schizoaffective disorder;
- Current primary diagnosis of anorexia nervosa or bulimia nervosa;
- Current psychosis;
- Drug and/or alcohol dependence or abuse within the past three months (episodic abuse related to mood episodes will not exclude a subject);
- Antisocial personality disorder (other Axis II disorders will not be exclusionary);
- Organic affective syndrome;
- Renal or liver disease;
- Epilepsy;
- Cardiovascular disease;
- Uncontrolled illnesses, including untreated hypertension or unstable endocrine diseases.
- Women who are or are plan to become pregnant during the course of this study
- Subjects who require inpatient treatment because of suicidal risk or psychosis
- Subjects with a well-documented history of an inability to tolerate one of the study treatments or are currently receiving treatment with an effective antidepressant therapy
Key Trial Info
Start Date :
April 1 2002
Trial Type :
INTERVENTIONAL
End Date :
September 1 2004
Estimated Enrollment :
35 Patients enrolled
Trial Details
Trial ID
NCT00222820
Start Date
April 1 2002
End Date
September 1 2004
Last Update
September 22 2005
Active Locations (1)
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1
Western Psychaitric Institute and Clinic
Pittsburgh, Pennsylvania, United States, 15213