Status:
COMPLETED
Clinical Trial of Lamotrigine to Reverse Cognitive Impairment in Chronic Corticosteroid-Treated Patients
Lead Sponsor:
University of Texas Southwestern Medical Center
Conditions:
Memory Impairment Due to Corticosteroid Use
Hypomania Due to Corticosteroid Use
Eligibility:
All Genders
18-65 years
Phase:
PHASE4
Brief Summary
The purpose of this study is to determine if lamotrigine therapy is associated with improvement in mood, memory and hippocampal size and function in patients receiving chronic corticosteroid therapy. ...
Eligibility Criteria
Inclusion
- Current Corticosteroid Use of 7 mg or more for 6+ months
- 18-65 years of age
Exclusion
- Primarily non-English speaking
- Pregnant/nursing woman
- Currently taking Depakote
- Currently taking Rifampin
- Has diagnosis of major depressive disorder, schizophrenia, PTSD, bipolar I or bipolar II (not related to corticosteroid use)
- Diseases with CNS involvement
- Is to start a brief steroid taper
- History of Alcohol/drug abuse/dependence
Key Trial Info
Start Date :
August 1 2002
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 1 2005
Estimated Enrollment :
28 Patients enrolled
Trial Details
Trial ID
NCT00223262
Start Date
August 1 2002
End Date
September 1 2005
Last Update
April 16 2019
Active Locations (1)
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1
The UT Southwestern Medical Center
Dallas, Texas, United States, 75390-8843