Status:
COMPLETED
Study Comparing Patients Taking Olanzapine and Patients Taking Aripiprazole on Learning of Vocational Skills
Lead Sponsor:
The University of Texas Health Science Center at San Antonio
Collaborating Sponsors:
Bristol-Myers Squibb
Conditions:
Schizophenia Disorder
Schizoaffective Disorder
Eligibility:
All Genders
18-52 years
Phase:
NA
Brief Summary
STUDY PURPOSE: To study whether patients who have schizophrenia or schizoaffective disorder and are randomly assigned to switch to aripiprazole prior to participation in a brief vocational skills trai...
Detailed Description
Many schizophrenia outpatients have cognitive deficits and poor vocational functioning. There is evidence from randomized controlled trials that vocational skills training is important in improving vo...
Eligibility Criteria
Inclusion
- DSM-IV diagnosis of schizophrenia or schizoaffective disorder
- Between ages of 18 and 52
- On olanzapine for a minimum of 3 months prior to participation
- Outpatient status for at least 3 months
- Vision and hearing intact or corrected to extent that will allow participation in vocational training and cognitive testing
- Score in impaired range on at least one test from a cognitive battery designed to be sensitive to impairments in schizophrenia
- Ability to participate in the informed consent process, as evidenced by an assessment of the capacity to give consent for research developed by the Maryland Psychiatric Research Center (DeRenzo et al., 1998).
Exclusion
- History of head injury, mental retardation or neurological disorder
- Below a 4th grade reading level (32) according to the WRAT-3
- Taking multiple atypical antipsychotics
- Taking any decanoate antipsychotic
- Hospitalization in last 3 months
- Employment
- Alcohol or drug abuse that interferes with functioning or medication compliance
Key Trial Info
Start Date :
January 1 2004
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2007
Estimated Enrollment :
43 Patients enrolled
Trial Details
Trial ID
NCT00223418
Start Date
January 1 2004
End Date
June 1 2007
Last Update
April 8 2013
Active Locations (1)
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1
The University of Texas Health Science Center at San Antonio
San Antonio, Texas, United States, 78229