Status:
COMPLETED
Cytokine Regulation of Periradicular Pain in Humans
Lead Sponsor:
The University of Texas Health Science Center at San Antonio
Collaborating Sponsors:
National Institutes of Health (NIH)
National Institute of Dental and Craniofacial Research (NIDCR)
Conditions:
Chronic Apical Periodontitis of Pulpal Origin
Eligibility:
All Genders
16-60 years
Brief Summary
This clinical trial evaluates the role of cytokines in patients needing root canal treatment with diagnosis of necrotic pulp and chronic apical periodontitis
Detailed Description
This study evaluates whether periradicular exudate concentrations of cytokines differ in patients experiencing pain and mechanical allodynia due to pulpal necrosis with an acute exacerbation of a chro...
Eligibility Criteria
Inclusion
- Patient must be at least 16 years of age.
- Clinical indication for Non-Surgical Root Canal Therapy (NSRCT).
- 1st or 2nd maxillary or mandibular molar
- Diagnosis must be Chronic Apical Periodontitis (CAP) with or without symptoms.
- Intact, mature apices.
- ASA I or II
Exclusion
- Failure to meet any of the above
- Previous NSRCT
- Previous pulpotomy or pulpectomy
- Suppurative apical periodontitis
- Patients taking medications which can affect their pain rating or medications which effect their immune system ( such as glucocorticoids)
Key Trial Info
Start Date :
October 1 2002
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
June 1 2008
Estimated Enrollment :
9 Patients enrolled
Trial Details
Trial ID
NCT00223470
Start Date
October 1 2002
End Date
June 1 2008
Last Update
March 9 2012
Active Locations (1)
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1
Univerity of Texas Health Science Center at San Antonio
San Antonio, Texas, United States, 78229