Status:
COMPLETED
Effect of Exercise on Blood Coagulation in Persons With Chronic Spinal Cord Injury
Lead Sponsor:
US Department of Veterans Affairs
Conditions:
Cardiovascular Disease
Spinal Cord Injury
Eligibility:
All Genders
18-65 years
Phase:
NA
Brief Summary
The purpose of this study is to determine if exercise affects the clotting of blood (hemostasis). The effect of exercise on hemostasis will be determined in persons with spinal cord injury, a populati...
Detailed Description
Regular moderate intensity physical exercise decreases platelet aggregability as a consequence of increasing levels of tissue plasminogen activator (tPA) and reducing levels of plasminogen activator i...
Eligibility Criteria
Inclusion
- SCI subjects (n=12) with stable chronic, complete paraplegia, (T1 to T10) and quadriplegia (C4 to C8) (for more than 1 year) will be recruited. The paraplegia subjects should be able to transfer independently in/out of a wheelchair.
Exclusion
- Ambulatory persons with SCI
- Less than 18 years or greater than 65 years old
- Chronic illness (dialysis)
- Evidence or history of heart and/or vessel disease (arrhythmias, ischemia at rest)
- Platelet or coagulation disorders
- Prescribed use of on aspirin or non-steroidal anti inflammatory drugs
- Active illness (sepsis, pressure sores)
- Uncontrolled spasticity
- Contractures (fixed) in upper extremity/lower extremity Heterotopic ossification at hips, knees, that limit range of motion while seated for FES
Key Trial Info
Start Date :
November 1 2003
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2006
Estimated Enrollment :
12 Patients enrolled
Trial Details
Trial ID
NCT00223912
Start Date
November 1 2003
End Date
December 1 2006
Last Update
September 16 2010
Active Locations (1)
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1
VA Medical Center, Bronx
The Bronx, New York, United States, 10468