Status:
TERMINATED
Early Tobacco Abstinence - 5
Lead Sponsor:
National Institute on Drug Abuse (NIDA)
Conditions:
Tobacco Use
Eligibility:
All Genders
18-60 years
Phase:
PHASE1
Brief Summary
This proposal will conduct a prospective examination of the clinical course (intensity, content and duration) of tobacco (nicotine) abstinence effects in male and female smokers who are either heavy/l...
Detailed Description
1. To compare male and female smokers, with and without current depressive symptoms, in a prospective study of the intensity, content \& duration of nicotine abstinence effects during an eight-day abs...
Eligibility Criteria
Inclusion
- 1\) between ages 18-60 years; (2) able to read and write English (3) SMOKER: Smoking \>10 cigarettes per day for at least 1 year, with CO \> 10 ppm, and blood cotinine concentration of 150 ng/ml or greater, FTND scores \> 5.
- (4) DEPRESSED SUBJECT: Not meeting SCID criteria for current major depression or more than one past major depressive episode, but having scores \> 10 on the CES-D indicating presence of depressive symptomatology (5) NON-DEPRESSED SUBJECT: Not meeting SCID criteria for current major depression or more than one past major depressive episode, CES-D scores \<10.
- (6) HEAVY DRINKER: Not meeting SCID criteria for current alcohol dependence; drinking 20 or more drinks per month.
- (7) LIGHT DRINKER: Not meeting SCID criteria for current alcohol dependence; drinking ten drinks or less per month
Exclusion
- Current dependence on cocaine, marijuana, opiates or alcohol
- Positive urine screen for marijuana, cocaine or opiates at any appointment after the intake appointment.
- Regular use of any psychoactive drugs including anxiolytics and antidepressants;
- Current major depression or other psychiatric conditions
- Subjects with any significant, untreated current medical conditions condition such as neurological, endocrine, cardiovascular, renal, liver, thyroid pathology or on medications for any recent medical events 6) Pregnant or lactating women -
Key Trial Info
Start Date :
Trial Type :
INTERVENTIONAL
End Date :
October 1 2004
Estimated Enrollment :
140 Patients enrolled
Trial Details
Trial ID
NCT00224965
End Date
October 1 2004
Last Update
January 12 2017
Active Locations (1)
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1
Yale University, Dept. of Psychiatry
Minneapolis, Minnesota, United States, 55415