Status:
COMPLETED
Long-Term Evaluation Follow-up of Neurocognitive Performance and Emotional State in Patients With Chronic Hepatitis C
Lead Sponsor:
University of Wuerzburg
Collaborating Sponsors:
Schering-Plough
Conditions:
Hepatitis C, Chronic
Eligibility:
All Genders
18-65 years
Brief Summary
This is a long-term evaluation follow-up study of neurocognitive performance and emotional state in patients with chronic hepatitis C infection and a former (peg)interferon alfa-2b-based therapy. M.R...
Detailed Description
This is a long-term evaluation follow-up study of neurocognitive performance and emotional state in patients with chronic hepatitis C infection and a former (peg)interferon alfa-2b-based therapy. M.R...
Eligibility Criteria
Inclusion
- Patients with chronic hepatitis C and indication for interferon-based antiviral therapy.
- Written informed consent to study participation, especially to long-term follow-up monitoring of psychiatric and neurocognitive side effects of combination therapy with (peg)interferon alfa-2b and ribavirin.
- Age of study participants: between 18 and 65 years.
- All patients need to have documented antibodies to hepatitis C virus (HCV) and circulating HCV-RNA as measured by reverse-transcription polymerase chain reaction (Cobas Amplicor HCV Monitor™ test, Roche Diagnostics)
Exclusion
- Insufficient knowledge of the German language or cognitive impairment (due to the indispensable application of questionnaires and the TAP, test battery of attentional performance).
- Further
Key Trial Info
Start Date :
July 1 2005
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
August 1 2008
Estimated Enrollment :
197 Patients enrolled
Trial Details
Trial ID
NCT00227149
Start Date
July 1 2005
End Date
August 1 2008
Last Update
February 4 2009
Active Locations (1)
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1
Med. Klinik und Poliklinik II, University of Wuerzburg
Würzburg, Germany, 97070