Status:
COMPLETED
Effect of Paroxetine on COAT-Platelet Production in Normal Volunteers and Patients With Cardiovascular Disease
Lead Sponsor:
University of Oklahoma
Collaborating Sponsors:
GlaxoSmithKline
Conditions:
Coronary Artery Disease
Eligibility:
All Genders
18-65 years
Phase:
PHASE4
Brief Summary
COAT-platelets stands for collagen and thrombin stimulated platelets, which are two things in the body that make platelets stick together. These platelets may be important in the initiation of a heart...
Eligibility Criteria
Inclusion
- normal volunteers (without heart disease)
- patients with heart disease
- between ages 18 \& 65
Exclusion
- children less than 18 years
- adults greater than 65 years
- those who can not keep appointments
- patients within 2 weeks of a coronary catheterization
- patients within 6 months of unstable angina or myocardial infarction
- individuals with allergies to paroxetine or similar medications
- individuals having adverse events to paroxetine or similar medications
- individuals with diagnosis of mania
- individuals with a diagnosis of hypomania
- individuals with a diagnosis of bipolar disorders
- individuals with a diagnosis of depression
- individuals with a diagnosis of panic disorders
- individuals with a diagnosis of seizure disorders
- individuals with a history of suicide attempts
- individuals with a diagnosis of hyponatremia
- individuals with active bleeding disorders
- individuals with a diagnosis of narrow angle glaucoma
- individuals with an estimated creatinine clearance of less that 30 ml/min
- individuals taking potentially interacting medications
Key Trial Info
Start Date :
March 1 2004
Trial Type :
INTERVENTIONAL
End Date :
May 1 2006
Estimated Enrollment :
25 Patients enrolled
Trial Details
Trial ID
NCT00229528
Start Date
March 1 2004
End Date
May 1 2006
Last Update
September 22 2008
Active Locations (1)
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1
The University of Oklahoma Health Sciences Center
Oklahoma City, Oklahoma, United States, 73190