Status:
TERMINATED
Intra-op Lidocaine and Ketamine Effect on Postoperative Bowel Function
Lead Sponsor:
University of Saskatchewan
Collaborating Sponsors:
Saskatoon Health Region
Conditions:
Colorectal Cancer
Eligibility:
All Genders
18-79 years
Phase:
NA
Brief Summary
Bowel function after bowel surgery is delayed (postoperative ileus)by both opiates and the surgery itself. We hypothesized that decreasing opiate use by other analgesics will speed the return of bowel...
Detailed Description
Introduction: Postoperative ileus is a normal response to the surgical handling of bowel that causes transient impairment of bowel motility after abdominal surgery. It is characterized by distension, ...
Eligibility Criteria
Inclusion
- age 18 to 79
- booked for urgent or elective colon surgery undergoing a left, right, or transverse hemicolectomy via laparotomy
Exclusion
- patients requiring emergency surgery
- pregnant subjects or those who might be pregnant
- subjects allergic to lidocaine, ketamine, morphine, naproxen, or acetaminophen
- subjects with epidural analgesia
- subjects unable to understand and implement a Patient-Controlled Intravenous Analgesia system
- subjects who do not know English well enough to understand the consent form and assessments
- subjects with known hepatic or renal failure or cardiac dysrhythmias or atrioventricular block
- patients with pre-existing functional bowel motility disorders including Crohn's disease and ulcerative colitis
- daily use of laxatives, inability to have a bowel movement without laxatives, use of suppositories or enemas on a daily basis, or use of antimotility agents
- patients with Parkinson's disease
Key Trial Info
Start Date :
September 1 2005
Trial Type :
INTERVENTIONAL
End Date :
November 1 2006
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT00229567
Start Date
September 1 2005
End Date
November 1 2006
Last Update
April 19 2007
Active Locations (1)
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1
Saskatoon Health Region, 410 22nd Street East
Saskatoon, Saskatchewan, Canada, S7K 5T6