Status:
RECRUITING
The Genetics and Functional Basis of Inherited Platelet, White Blood Cell, Red Blood Cell, and Blood Clotting Disorders.
Lead Sponsor:
Rockefeller University
Collaborating Sponsors:
National Heart, Lung, and Blood Institute (NHLBI)
Conditions:
Glanzmann Thrombasthenia
Eligibility:
All Genders
Brief Summary
Blood contains red blood cells, white blood cells, and platelets, as well as a fluid portion termed plasma. We primarily study blood platelets, but sometimes we also analyze the blood of patients with...
Detailed Description
After volunteers and family members agree to participate, they are seen in the Outpatient Research Center by the Principal Investigator or another physician. A detailed history is obtained, a physical...
Eligibility Criteria
Inclusion
- A. Normal Healthy Volunteers:
- Normal healthy volunteers
- 18 years of age or older
- Either sex
- Any ethnic background.
- B. Patients with Glanzmann thrombasthenia or their relatives, inherited qualitative and/or quantitative platelet disorders, inherited disorders of white blood cells, inherited disorders of coagulation (including von Willebrand disease):
- Adults and children
- Either sex
- Any ethnic background
Exclusion
- A. Normal Healthy Volunteers:
- For studies of platelets that may be affected by anti-platelet therapy, ingestion of aspirin or similar medication in the past week.
- Having given blood in the last 8 weeks such that the current donation would exceed a total of 250 ml for the 8 week period.
- Having given blood in the past week such that this donation would result in more than 2 donations in one week.
- B. Patients with Glanzmann thrombasthenia or their relatives, inherited qualitative and/or quantitative platelet disorders, inherited disorders of white blood cells, inherited disorders of coagulation (including von Willebrand disease).
- For studies of platelets that may be affected by antiplatelet therapy, ingestion of aspirin or similar medication in the past week
- If the patient is known to have a hematocrit ≥25 (assay performed in past 3 months), the same blood drawing criteria as in A, with the addition that for children less than 18 years of age, the maximum amount of blood allowed to be donated in an 8 week period is the lesser of 50 ml or 3 ml/kg.
- If the patient has a hematocrit \<25 or if the hematocrit is unknown, the blood drawing limit is the lesser of 20 ml or 1 ml/kg in any 8 week period.
Key Trial Info
Start Date :
September 1 2005
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
June 1 2030
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT00230165
Start Date
September 1 2005
End Date
June 1 2030
Last Update
October 17 2025
Active Locations (1)
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1
Rockefeller University Hospital
New York, New York, United States, 10021