Status:
COMPLETED
Randomised Controlled Clinical Trials of the Effect of Therapeutic Hookworm Infection in Allergic Rhinoconjunctivitis
Lead Sponsor:
University of Nottingham
Conditions:
Rhinitis, Allergic, Perennial
Hayfever
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
There has been considerable debate over the last 30 years about the interaction between asthma and parasitic infection. It has been suggested that at least part of the reason for the increasing preval...
Detailed Description
Epidemiological evidence suggests that human hookworm infection is associated with a reduced risk of asthma and allergic disease. This association is potentially important not only to understanding th...
Eligibility Criteria
Inclusion
- Symptoms of allergic rhinitis
- Measurable airway responsiveness to AMP
- Negative hookworm serology
- Positive skin prick tests to D.pteronyssinum, cat fur or grass pollen
Exclusion
- History of asthma
- History of anaemia
- History of severe allergic reaction or anaphylaxis
- Possible or planned pregnancy
Key Trial Info
Start Date :
September 1 2005
Trial Type :
INTERVENTIONAL
End Date :
November 1 2006
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT00232518
Start Date
September 1 2005
End Date
November 1 2006
Last Update
May 7 2007
Active Locations (1)
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1
University of Nottingham
Nottingham, United Kingdom, NG5 1PB