Status:
COMPLETED
Investigation of a Combination Treatment of Escitalopram and rTMS
Lead Sponsor:
Charite University, Berlin, Germany
Collaborating Sponsors:
H. Lundbeck A/S
Conditions:
Major Depressive Disorder
Eligibility:
All Genders
18-85 years
Phase:
NA
Brief Summary
We intend to test in a randomized, rater blinded, placebo controlled, prospective study the primary hypothesis that an escitalopram-rTMS-combination treatment is more efficacious in the treatment of r...
Detailed Description
We intend to test in a randomized, rater blinded, placebo controlled, prospective study the primary hypothesis that an escitalopram-rTMS-combination treatment is more efficacious in the treatment of r...
Eligibility Criteria
Inclusion
- Major Depressive Episode (according to DSM IV standards)
- HAMD \> 20
- Patient has an IQ \> 70 based on the investigator´s judgement
- Patient is male or nonpregnant female adequately protected from conception
- Patient is able to comply with all testing and follow-up visit requirements defined by the study protocol
- Patient has voluntarily signed an informed consent in accordance with institutional policies
Exclusion
- Patient has a history of schizophrenia, schizoaffective disorder or delusional disorder
- Patient currently has a secondary diagnosis of, or signs of, delirium, dementia, amnestic or other cognitive disorder per DSM IV
- Patient is suicidal
- Patient has had an alcohol or substance dependence within the previous 12 month
- Patient is currently enrolled in another investigational study
- Patient has a history of, or evidence of, significant central nervous disease (especially seizures)
- Patient has previously been treated with escitalopram
- Contraindication against escitalopram or rTMS
Key Trial Info
Start Date :
September 1 2005
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2008
Estimated Enrollment :
42 Patients enrolled
Trial Details
Trial ID
NCT00232700
Start Date
September 1 2005
End Date
December 1 2008
Last Update
June 23 2011
Active Locations (1)
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1
Department of Psychiatry, Charité - Universitaetsmedizin Berlin, Campus Benjamin Franklin
Berlin, Germany, 14050