Status:
COMPLETED
The Effect of Fructose on Blood Fats in Dialysis Patients and Healthy Volunteers
Lead Sponsor:
Rockefeller University
Collaborating Sponsors:
Robert C. Atkins Foundation
The Rogosin Institute
Conditions:
End-stage Renal Disease
Eligibility:
All Genders
18-75 years
Phase:
NA
Brief Summary
This study will evaluate how a common dietary sugar (fructose) raises blood fats (triglycerides). We will determine whether the production of fat from fructose is higher in dialysis patients compared ...
Detailed Description
Fifteen hemodialysis patients and 15 healthy volunteers will be studied. Outpatient screening visit(s): consent, fasting blood and urine analysis, a physical exam, an EKG and a 2-hour oral glucose to...
Eligibility Criteria
Inclusion
- Male and females, 18-75 years of age.
- Chronic renal failure with hemodialysis 3x/week for at least 6 months and adequate dialysis as judged by a nephrologist who is not a study investigator.
- Fasting TG \<600 mg/dl, LDL cholesterol \<190 mg/dl (off lipid-lowering medication)
- Willing and able to change Renagel, a noncalcemic phosphate binder (poly\[allylamine hydrochloride\]) which has LDL-lowering effects, to the same amount of another phosphate binder for 1 month prior to the screening visit until the completion of the study.
- Willing and able to temporarily stop Sensipar (cinacalcet) for 1 week before the study admission until completion of the study (a total of \~2 weeks).
- Willing and able to stop ASA (except low dose ASA in patients with vascular disease), NSAID, fish oil, psyllium, other nonprescribed vitamins/supplements for 1 week prior to study until completion of study.
- Willing and able to sign an informed consent.
- Willing to refrain from participation in an investigational drug study for the duration of the study.
Exclusion
- Diabetes (fasting blood sugar \>126 twice or an abnormal 2 hour OGTT)
- Unstable clinical condition, including acute febrile illness within 1 month of admission
- Chronic infection, including hepatitis and HIV infection
- Gastrointestinal disease resulting in significant GI dysfunction or malabsorption
- Lipid-lowering medication
- Mean systolic blood pressure \>180 or diastolic pressure \>110 taken immediately before 6 dialysis treatments over the 2 weeks before the screening visit 7/15/2008 Form version 6/13/2005 #LHU-0471-0407 Page 8of 16f
- BMI \>35 (markedly obese)
- Hemoglobin \<10.0
- Prednisone, estrogen/progesterone, other steroids, Synthroid, endocrine disease
- Coumadin and an INR \>1.5
- Cigarette smoking \>1/2 pack/day
- Abuse of ethanol (greater than 2 drinks/day) or illicit drugs
- If female, pregnant or breast feeding
- Participation in a study of an investigational drug during the 30 days preceding the start of the screening period
- Have any other condition, which in the opinion of the investigator, should prohibit the participation in the study
- Healthy Controls:
- Inclusion Criteria
- 1\. Male and females, 18-75 years of age 2. LDL \<160 mg/dl, HDL-C \>30 mg/dl, TG \<250 mg/dl 3. Willing and able to stop ASA, NSAID, fish oil, psyllium, other vitamins/supplements for 1 week prior to study until completion of study 4. Willing and able to sign an informed consent 5. Willing to refrain from participation in an investigational drug study for the duration of the study Exclusion Criteria
- Systemic illnesses, including diabetes (FBS \>126 twice or abnormal OGTT), cardiovascular disease, hepatitis, endocrine disease, HIV infection.
- Prescription medications, including contraceptives.
- Acute febrile illness within 1 month of admission.
- BMI \>35 (markedly obese) or\>10% below maximum weight.
- Weight change of \>10% usual weight in the previous 6 months.
- Blood pressure \>140/90.
- HB \<11 female, \<12 male.
- CRP \>5.0 on 2 occasions. 7/15/2008 Form version 6/13/2005 #LHU-0471-0407 Page 9of 16f
- Abuse of ethanol (greater than 2 drinks/day) or illicit drugs.
- Cigarette smoking \>1/2 pack/day.
- Unusual diet or extreme physical activity (e.g. marathon runner).
- If female, pregnant or breast feeding.
- Participation in a study of an investigational drug during the 30 days preceding the start of the screening period.
- Have any other condition, which in the opinion of the investigator, should prohibit the participation in the study.
Key Trial Info
Start Date :
September 1 2004
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 1 2009
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT00234156
Start Date
September 1 2004
End Date
October 1 2009
Last Update
January 11 2012
Active Locations (1)
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1
Rockefeller University Hospital
New York, New York, United States, 10021