Status:
COMPLETED
Effect of Paracetamol, Pregabalin and Dexamethasone on Pain and Opioid Requirements in Patients After Hip Operations
Lead Sponsor:
Glostrup University Hospital, Copenhagen
Conditions:
Pain
Postoperative
Eligibility:
All Genders
55-75 years
Phase:
PHASE4
Brief Summary
Patients scheduled for primary total hip replacement needs postoperative pain treatment: i.e. morphine. Unfortunately morphine has side-effects: nausea, vomiting, sedation and dizziness, which is unpl...
Detailed Description
We investigate the effect of paracetamol versus paracetamol + pregabalin versus paracetamol + pregabalin + dexamethasone on pain and morphine usage in the first 24 hours postoperatively in patients ge...
Eligibility Criteria
Inclusion
- Patients scheduled for primary total hip replacement in spinal anaesthesia
- between the age of 55 and 75,
- ASA 1-3, and with
- BMI between 18 and 35.
Exclusion
- are unable to cooperate;
- does not speak Danish;
- has allergy for drugs used in the trial;
- has drug and/or medicine abuse;
- epilepsy;
- diabetes treated with medicine;
- treatment with systemic steroids within 4 weeks prior to the operation;
- daily use of antacids;
- daily use of analgesics except for NSAID, Cox2 inhibitors and Paracetamol;
- known kidney disease;
- use of antidepressants
Key Trial Info
Start Date :
October 1 2005
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 1 2007
Estimated Enrollment :
120 Patients enrolled
Trial Details
Trial ID
NCT00235261
Start Date
October 1 2005
End Date
June 1 2007
Last Update
August 17 2007
Active Locations (1)
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1
Department of anaesthesiology; Hoersholm Sygehus
Hoersholm, Frederiksborg Amt, Denmark, 2970