Status:
COMPLETED
The IGFBP-3 Stimulation Test: A New Tool for the Diagnosis of Growth Hormone Deficiency in Children.
Lead Sponsor:
University of Massachusetts, Worcester
Conditions:
Short Stature
Growth Hormone Deficiency
Eligibility:
All Genders
4-12 years
Brief Summary
This project is designed to answer the question: Is there an acute IGFBP-3 response in normal children? Our specific hypothesis states that under the influence of growth hormone secretagogues, intact...
Detailed Description
The diagnosis of growth hormone deficiency is problematic, given the shortcoming of the standard growth hormone stimulation test. This study is designed to investigate a new tool for the diagnosis of ...
Eligibility Criteria
Inclusion
- Bone age \< 10 years female, \< 12 years male
- Pubertal status: Girls: Tanner I for breast development. Boys: testicular volume of ≤ 3 cc, as measured by the standardized orchidometer (Prader type). The onset of pubic hair development up to and including Tanner III is allowed in the study.
- Adequate nutrition: body mass index ≥ 25th percentile for gender.
Exclusion
- Syndromic short stature
- Chronic illnesses.
- Other disorders, including osteo- or chondrodystrophies, and endocrine causes of short stature such as Cushing syndrome, and untreated hypothyroidism.
Key Trial Info
Start Date :
September 1 2005
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
October 1 2006
Estimated Enrollment :
10 Patients enrolled
Trial Details
Trial ID
NCT00235599
Start Date
September 1 2005
End Date
October 1 2006
Last Update
May 17 2007
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
University of Massachusetts Medical School
Worcester, Massachusetts, United States, 01655