Status:
UNKNOWN
Intravenous Metoclopramide for the Treatment of Post Concussive Headache: a Randomized Placebo Controlled Trial
Lead Sponsor:
Vancouver General Hospital
Conditions:
Post Concussive Headache
Post Concussive Syndrome
Eligibility:
All Genders
19+ years
Phase:
NA
Brief Summary
Concussion is defined as any temporary disturbance in brain function following a blow to the head. It may not involve a loss of consciousness and usually results in a post concussive headache (PCH) im...
Detailed Description
PURPOSE AND OBJECTIVES The primary objective of this study is to prospectively evaluate the effect of metoclopramide in ED patients with minor head injury. The primary hypothesis is that the administr...
Eligibility Criteria
Inclusion
- Only patients who meet the following inclusion criteria will be recruited:
- History of blunt head trauma within preceding 24 hours.
- Immediate and transient post traumatic impairment of neurological functions defined as alteration of consciousness, amnesia, disorientation, disturbance of vision or equilibrium (10).
- Onset of headache within one hour of trauma.
Exclusion
- Patients with any of the following exclusion criteria will not be enrolled:
- Age less than or equal to 19 years.
- Known or suspected pregnancy.
- Known hypersensitivity or intolerance to metoclopramide.
- Inability to give informed consent.
- Known gastrointestinal hemorrhage, perforation or obstruction.
- Known seizure disorder.
- Known pheochromocytoma.
- Concurrent significant CNS depression due to drugs or alcohol.
- Concurrent treatment for psychiatric illness.
- Any acute brain injury on CT scan (if performed) as defined by any radiographic finding which would normally require admission to hospital and neurological follow up
Key Trial Info
Start Date :
May 1 2004
Trial Type :
INTERVENTIONAL
End Date :
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT00237705
Start Date
May 1 2004
Last Update
December 5 2006
Active Locations (1)
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1
Vancouver General Hospital
Vancouver, British Columbia, Canada, V5Z 1M9