Status:
COMPLETED
Thyroxine Replacement in Organ Donors
Lead Sponsor:
London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Conditions:
Brain Death
Eligibility:
All Genders
16+ years
Phase:
PHASE1
PHASE2
Brief Summary
To compare oral versus intravenous administration of thyroid hormone: 1) for reversibility of hemodynamic instability in organ donors, and, 2) the pharmacokinetics of oral vs iv thyroid administration
Detailed Description
Disruption of the hypothalamic-pituitary axis following brain death may lead to hemodynamic instability, peripheral vasodilation, and diabetes insipidus in organ donors, requiring the use of high dose...
Eligibility Criteria
Inclusion
- Brain death criteria established
- Consent for organ donation received
Exclusion
- 1\. immediate (\< 4 Hrs) organ retrieval anticipated
Key Trial Info
Start Date :
December 1 2004
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 1 2010
Estimated Enrollment :
34 Patients enrolled
Trial Details
Trial ID
NCT00238030
Start Date
December 1 2004
End Date
October 1 2010
Last Update
January 5 2011
Active Locations (1)
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1
London Health Sciences Centre-UC
London, Ontario, Canada, N6A5A5