Status:
COMPLETED
PPV: Pneumococcal Polysaccharide Vaccine in Older Adults
Lead Sponsor:
National Institute on Aging (NIA)
Conditions:
Aging
Eligibility:
All Genders
65+ years
Phase:
PHASE4
Brief Summary
The purpose of this study is to measure how long the improvement in the immune system lasts in older people after they have been vaccinated, and to examine the immune response in older people who get ...
Detailed Description
Streptococcus pneumonia is the leading cause of pneumonia the United States, estimated to cause at least 500,000 cases annually and 40,000 deaths. Interest in expanding pneumococcal vaccine administra...
Eligibility Criteria
Inclusion
- Enrolled in the BLSA with at least 2 stored blood samples post vaccination
- 65 years old or older
- Previously vaccinated with Pneumovax at least 5 years ago or never vaccinated
- Willing to receive vaccination with pneumococcal and meningococcal injection
- Able to provide informed consent
- Has never received a meningococcal vaccine
Exclusion
- Hypersensitivity to the pneumococcal or meningococcal vaccine
- Ever received the Meningococcal vaccine
- History of non-skin cancer
- History of myeloproliferative disorder
- History of HIV
- Received a Bone Marrow Transplant
- Taking prednisone (more than 5 mg/day) or other immunosuppressive medication
- Evidence of severe liver or renal disease (serum creatine \>2.0 mg/dL or Total Bilirubin \>2.0
Key Trial Info
Start Date :
April 1 2001
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 1 2012
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT00239694
Start Date
April 1 2001
End Date
August 1 2012
Last Update
August 4 2015
Active Locations (1)
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1
National Institute on Aging
Baltimore, Maryland, United States, 21225