Status:
COMPLETED
MIRAGE: Multi-Institutional Research in Alzheimer's Genetic Epidemiology
Lead Sponsor:
National Institute on Aging (NIA)
Conditions:
Alzheimer's Disease
Eligibility:
All Genders
50+ years
Brief Summary
The goal of MIRAGE is to evaluate the association of genetic and non-genetic risk factors for Alzheimer's Disease.
Detailed Description
For the past 13 years the MIRAGE project has demonstrated that genetic factors play a major role in the development of Alzheimer's Disease (AD) among patients ascertained in clinical settings. This re...
Eligibility Criteria
Inclusion
- NOTE: This trial accepts patients with Probable AD, and their cognitively normal brothers or sisters
- Probable or definite AD by NINCDS-ADRDA criteria
- Living siblings who are cognitively normal as measured by a brief standardized cognitive assessment
- Ages 60 and over for Alzheimer's disease patients
- Ages 50 and over for cognitively normal siblings
Exclusion
- Early onset Alzheimer's disease attributed to APP, PS1 or PS2 gene mutations
- History of clinical stroke
- Siblings whose cognitive assessment does not meet study criteria
- Pacemaker or other contraindication to MRI
Key Trial Info
Start Date :
September 1 2002
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
June 1 2008
Estimated Enrollment :
2000 Patients enrolled
Trial Details
Trial ID
NCT00239759
Start Date
September 1 2002
End Date
June 1 2008
Last Update
February 25 2009
Active Locations (15)
Enter a location and click search to find clinical trials sorted by distance.
1
University of Alabama
Birmingham, Alabama, United States, 35233
2
Sun Health Research Institute
Sun City, Arizona, United States, 85351
3
Rancho Los Amigos National Rehabilitation Center/University of Southern California
Downey, California, United States, 90242
4
University of California, Davis
Sacramento, California, United States, 95817