Status:
TERMINATED
Prazosin for ETOH or Cocaine Craving
Lead Sponsor:
US Department of Veterans Affairs
Conditions:
Alcoholism
Cocaine Dependence
Eligibility:
All Genders
18-70 years
Phase:
NA
Brief Summary
This double-blind placebo controlled crossover pilot trial will test the hypothesis that prazosin, an alpha-1 adrenergic receptor antagonist, reduces craving for their drug of choice in cocaine-depend...
Detailed Description
1. Objective of the project: To evaluate the efficacy of prazosin on the reduction of craving in alcohol and cocaine dependent individuals. The investigators hypothesize that prazosin will be more eff...
Eligibility Criteria
Inclusion
- Age 18-70 years
- Current DSM-IV diagnosis of alcohol dependence or cocaine dependence with no use in last 30 days
- Capacity to provide informed consent
- Actively enrolled in chemical dependency treatment at VA Puget Sound English fluency
Exclusion
- Evidence of significant abuse of opiates, PCP, sedatives or anxiolytics
- Suicidal ideation
- DSM IV diagnosis of bipolar mood disorder, schizophrenia or schizoaffective disorder
- Significant acute or chronic medical illness, including unstable angina, recent myocardial infarction, history of congestive heart failure, preexisting hypotension (systolic \< 110), or orthostatic hypotension (systolic drop \> 20mmHg after two minutes standing or any drop with dizziness), insulin-dependent diabetes mellitus; chronic renal or hepatic failure, pancreatitis, gout, M ni re's disease, benign positional vertigo, narcolepsy
- Concomitant use of alpha-1 antagonists History of prazosin-sensitivity Women who are pregnant, nursing infant(s), or of childbearing potential and not using a contraceptive method judged by the investigator to be effective
- Non-compliance with outpatient chemical dependency treatment
Key Trial Info
Start Date :
April 1 2004
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 1 2009
Estimated Enrollment :
8 Patients enrolled
Trial Details
Trial ID
NCT00240227
Start Date
April 1 2004
End Date
January 1 2009
Last Update
August 31 2018
Active Locations (1)
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1
VA Puget Sound Health Care System
Seattle, Washington, United States, 98109