Status:
UNKNOWN
A Comparison of Two Anaesthetic Methods of Protecting Heart Tissue During Cardiac Surgery
Lead Sponsor:
Golden Jubilee National Hospital
Collaborating Sponsors:
European Society for Intravenous Anaesthesia
Conditions:
Coronary Artery Bypass Surgery
Eligibility:
All Genders
40-80 years
Phase:
PHASE4
Brief Summary
To compare two different methods of protecting heart muscle from damage caused by a decreased blood supply. Exposure to the anaesthetic agent sevoflurane can allow the heart muscle to resist longer pe...
Detailed Description
Coronary artery bypass grafting (CABG) is a common procedure performed to improve blood flow to the heart in patients with severe ischaemic heart disease. Commonly, the heart has to be stopped to allo...
Eligibility Criteria
Inclusion
- Patients presenting for elective CABG operations, with \>40 % left ventricular ejection fraction, aged 40-80.
Exclusion
- Patients at risk of epidural haematomas (i.e. platelets \<100, coagulopathies, on anticoagulant therapies, INR\>1.4) or unsuited to HTEA (patient refusal, spinal deformities).
- Patients on drugs shown to manipulate the preconditioning phenomenon will also be excluded. This includes those on diazoxide, nicorandil, oral sulfonylureas and theophyllines.
- Patients with preoperative ECG morphologies likely to make interpretation difficult or impossible including: left bundle branch block, cardiac pacemaker dependence.
- Haemodynamically compromised patients requiring inotropic or balloon pump support preoperatively.
- Significant valvular disease. Preoperative elevated levels of troponin I or CKMB. Unstable angina or angina in 24 hours preop
Key Trial Info
Start Date :
January 1 2006
Trial Type :
INTERVENTIONAL
End Date :
January 1 2008
Estimated Enrollment :
150 Patients enrolled
Trial Details
Trial ID
NCT00244283
Start Date
January 1 2006
End Date
January 1 2008
Last Update
October 26 2005
Active Locations (1)
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1
Golden Jubilee National Hospital
Glasgow, United Kingdom, G81 4HX