Status:
COMPLETED
Examine the Possible Association of Hepatic CYP3A Activity and the Susceptibility to Femur Head Necrosis
Lead Sponsor:
Osaka City University
Conditions:
Femur Head Necrosis
Eligibility:
All Genders
14-70 years
Brief Summary
The purpose of the present study was to examine the possible association of hepatic CYP3A activity and the susceptibility to femur head necrosis in patients treated with corticosteroids.
Detailed Description
Femur head necrosis is one of the major side effects of corticosteroid therapy. Since corticosteroids are metabolized by hepatic cytochrome P-450 (CYP) 3A, a low endogenous activity of this enzyme may...
Eligibility Criteria
Inclusion
- Clinical diagnosis of avascular necrosis of the femur
Exclusion
- Old age (\> 70 years)
- Severe hepatic or renal dysfunction
- Heart disease
- Current use of known CYP3A-inducing or -inhibiting drugs
- Morbid obesity
Key Trial Info
Start Date :
November 1 2002
Trial Type :
OBSERVATIONAL
End Date :
January 1 2006
Estimated Enrollment :
200 Patients enrolled
Trial Details
Trial ID
NCT00244400
Start Date
November 1 2002
End Date
January 1 2006
Last Update
October 17 2006
Active Locations (1)
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1
Graduate School of Medicine, Osaka City University
Osaka, Osaka, Japan, 545-8585