Status:
TERMINATED
DIAFAX I+II-Effects of Inhalative Anesthetics on Left Ventricular Diastolic Function
Lead Sponsor:
University Hospital, Basel, Switzerland
Conditions:
Young Healthy Adults
Ventricular Dysfunction
Eligibility:
All Genders
50+ years
Phase:
PHASE4
Brief Summary
Anaesthetics may impair the diastolic function of the heart, but the importance of this finding for patients has not been sufficiently examined. Specially the effects on diastolic function in patients...
Detailed Description
In part I, 60 healthy young subjects free from cardiovascular disease will be examined. In part II, 50 patients with impaired diastolic but preserved systolic function, i.e., patients with arterial hy...
Eligibility Criteria
Inclusion
- part I: 18- to 50-year-old patients undergoing surgical procedures under general anesthesia
- part II: 50-years-old patients or older with arterial hypertension under chronic antihypertensive medication subsequently undergoing surgical procedures under general anesthesia, EF \>50%
Exclusion
- part I: any cardiac or pulmonary disease, any medication with cardiovascular effects or side effects, body mass index \> 30 kg/m2, esophageal reflux, emergency
- part II: History of myocardial infarction or coronary revascularization, severe lung disease, body mass index \> 30 kg/m2, esophageal reflux, emergency
Key Trial Info
Start Date :
June 1 2004
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 1 2010
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT00244517
Start Date
June 1 2004
End Date
April 1 2010
Last Update
July 1 2010
Active Locations (1)
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1
University Hospital
Basel, CH, Switzerland, 4000