Status:
COMPLETED
Prophylactic Effect of Nifedipine on Further Decline in Renal Function in Patients Undergoing Open-Heart Surgery
Lead Sponsor:
University of Oslo School of Pharmacy
Conditions:
Kidney Failure, Chronic
Coronary Artery Disease
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
To compare renal function (51Cr-EDTA clearance) 48 hours post open-heart surgery (coronary bypass or valve surgery) in patients with impaired renal function after randomization to either nifedipine in...
Eligibility Criteria
Inclusion
- Patients of either gender above 18 years of age.
- Patients with significant coronary stenosi(e)s (≥ 75% coronary artery lumen surface stenosi(e)s and / or aortic- or mitral valve vitriuim that are accepted for coronary artery bypass surgery and/or valve replacement surgery.
- Patients with impaired renal function, defined as increased serum- creatinine. Men: ≥ 150 µmol/l and Women: ≥130 µmol/l.
Exclusion
- Patients on maintenance hemodialysis
- Renal transplant patients
- Patients with ejection fraction ≤ 35%
- Patients with unstable angina pectoris
Key Trial Info
Start Date :
June 1 2001
Trial Type :
INTERVENTIONAL
End Date :
October 1 2005
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT00244530
Start Date
June 1 2001
End Date
October 1 2005
Last Update
December 22 2006
Active Locations (1)
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1
Rikshospitalet University Hospital
Oslo, Norway, 0027