Status:
COMPLETED
Gemcitabine Hydrochloride and Genistein in Treating Women With Stage IV Breast Cancer
Lead Sponsor:
Barbara Ann Karmanos Cancer Institute
Collaborating Sponsors:
National Cancer Institute (NCI)
Conditions:
Breast Cancer
Eligibility:
FEMALE
18-120 years
Phase:
PHASE2
Brief Summary
RATIONALE: Drugs used in chemotherapy, such as gemcitabine hydrochloride and genistein, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from d...
Detailed Description
OBJECTIVES: Primary * Determine the objective response rate in patients with stage IV breast cancer treated with gemcitabine hydrochloride and genistein. Secondary * Determine the duration of resp...
Eligibility Criteria
Inclusion
- DISEASE CHARACTERISTICS:
- Histologically or cytologically confirmed breast cancer
- Stage IV disease
- Clinical and/or radiological evidence of metastatic disease
- Measurable disease
- Prior radiotherapy allowed provided there is ≥ 1 measurable disease site outside the radiation field
- No active CNS metastases
- Previously treated CNS metastases allowed provided disease is stable for ≥ 3 months without steroids or antiseizure medications
- Hormone receptor status:
- Not specified
- PATIENT CHARACTERISTICS:
- Sex
- Female
- Menopausal status
- Not specified
- Performance status
- SWOG 0-2
- Life expectancy
- Not specified
- Hematopoietic
- Absolute neutrophil count ≥ 1,500/mm\^3
- Platelet count ≥ 100,000/mm\^3
- Hemoglobin ≥ 10 g/dL
- Hepatic
- Bilirubin ≤3.0 mg/dL
- AST and ALT ≤ 2.5 times upper limit of normal
- Renal
- Creatinine ≤ 1.5 mg/dL
- Other
- Not pregnant or nursing
- Fertile patients must use effective contraception
- No serious systemic disorder that would preclude study compliance
- No history of another malignancy except curatively treated carcinoma of the cervix or basal cell or squamous cell skin cancer in complete remission
- No unresolved bacterial infection requiring antibiotic treatment
- No known HIV-1 positivity
- PRIOR CONCURRENT THERAPY:
- Biologic therapy
- At least 3 weeks since prior biologic therapy
- Chemotherapy
- Prior adjuvant chemotherapy allowed
- Prior adjuvant or neoadjuvant taxane-based therapy or taxane therapy for metastatic disease allowed
- Patient must have failed therapy within 2 years after completion of treatment
- At least 3 weeks since prior chemotherapy
- No more than 2 prior cytotoxic chemotherapy regimens for metastatic disease
- No prior gemcitabine hydrochloride
- No other concurrent chemotherapy
- Endocrine therapy
- See Disease Characteristics
- At least 2 weeks since prior and no concurrent hormonal therapy
- Must have documented disease progression during prior hormonal therapy
- Radiotherapy
- See Disease Characteristics
- At least 4 weeks since prior radiotherapy and recovered
- No concurrent radiotherapy
- Surgery
- At least 3 weeks since prior surgery
- Other
- At least 3 weeks since prior investigational therapy
- At least 1 week since prior soy supplements (e.g., soy-based pills, liquids, or concentrates)
- Dietary soy as part of a meal (e.g., tofu) allowed once a week
- No concurrent nutritional supplements, herbal agents, or high doses of antioxidants (e.g., vitamins C, D, or E) that may interact with, antagonize, alter, or imitate the potential effects of gemcitabine hydrochloride or genistein
- A single daily multivitamin is allowed
- No other concurrent immunotherapy
- No other concurrent experimental medication
- Concurrent anticoagulants, appetite stimulants, and replacement steroids allowed
Exclusion
Key Trial Info
Start Date :
February 1 2004
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 1 2009
Estimated Enrollment :
19 Patients enrolled
Trial Details
Trial ID
NCT00244933
Start Date
February 1 2004
End Date
October 1 2009
Last Update
June 22 2023
Active Locations (1)
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1
Barbara Ann Karmanos Cancer Institute
Detroit, Michigan, United States, 48201-1379