Status:
COMPLETED
Pharmacogenomic Evaluation of Antihypertensive Responses
Lead Sponsor:
University of Florida
Conditions:
Hypertension
Eligibility:
All Genders
17-65 years
Phase:
PHASE4
Brief Summary
There are many medications available for the treatment of high blood pressure (hypertension), but finding the right one for a specific patient can be challenging. In fact, it is estimated that only 34...
Detailed Description
The proposed work should help move toward the long-term goal of selection of antihypertensive drug therapy based on a patient's genetic make-up. Hypertension (HTN) is the most common chronic disease f...
Eligibility Criteria
Inclusion
- An average seated home diastolic blood pressure (DBP) \> 85 mmHg and home systolic blood pressure (SBP) \< 180 mmHg. Subjects must also have an average seated (\> 5 minutes) clinic DBP between 90 mmHg and 110 mmHg and SBP \< 180 mmHg
Exclusion
- secondary forms of HTN, patients currently treated with three or more antihypertensive drugs, isolated systolic HTN, other diseases requiring treatment with BP lowering medications, heart rate \< 55 beats/min, known cardiovascular disease (including history of angina pectoris, heart failure, presence of a cardiac pacemaker, history of myocardial infarction or revascularization procedure, or cerebrovascular disease, including stroke and TIA), diabetes mellitus (Type 1 or 2), renal insufficiency (serum creatinine \> 1.5 in men or 1.4 in women), primary renal disease, pregnancy or lactation, liver enzymes \> 2.5 upper limits of normal, current treatment with NSAIDS, cyclooxygenase-2 (COX2) inhibitors, oral contraceptives or estrogen.
Key Trial Info
Start Date :
October 1 2005
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2010
Estimated Enrollment :
1701 Patients enrolled
Trial Details
Trial ID
NCT00246519
Start Date
October 1 2005
End Date
December 1 2010
Last Update
May 7 2018
Active Locations (3)
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1
University of Florida Department of Community Health and Family Medicine
Gainesville, Florida, United States, 32610
2
Emory University
Atlanta, Georgia, United States, 30322
3
Mayo Clinic
Rochester, Minnesota, United States, 55905