Status:
COMPLETED
Opiate-Induced Tolerance & Hyperalgesia in Pain Patients
Lead Sponsor:
National Institute of General Medical Sciences (NIGMS)
Conditions:
Chronic Low Back Pain
Opioid-induced Hyperalgesia
Eligibility:
All Genders
18-70 years
Phase:
PHASE4
Brief Summary
Opiates such as morphine are the cornerstone medications for the treatment of moderate to severe pain. Recent evidence suggests that pain patients on chronic opioid therapy become more sensitive to pa...
Eligibility Criteria
Inclusion
- opioid naïve (or less than 4 vicodin equiv/day)
- 18-70 years old
- candidate for opioid therapy for nonmalignant pain.
Exclusion
- history of substance abuse or severe psychiatric disease
- use of medications for the treatment of neuropathic pain as these may alter tolerance or hyperalgesia
- neurological conditions interfering with experimental pain testing, e.g. severe peripheral neuropathy
Key Trial Info
Start Date :
October 1 2005
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 1 2009
Estimated Enrollment :
139 Patients enrolled
Trial Details
Trial ID
NCT00246532
Start Date
October 1 2005
End Date
August 1 2009
Last Update
April 30 2012
Active Locations (1)
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1
Stanford University School of Medicine
Stanford, California, United States, 94025