Status:
COMPLETED
Effect of Regular Exercise on Vascular Function and Cardiovascular Risk in a Sedentary Work Force
Lead Sponsor:
National Heart, Lung, and Blood Institute (NHLBI)
Conditions:
Vascular Formation
Eligibility:
All Genders
Phase:
PHASE2
Brief Summary
This study will evaluate the effects of NHLBI's employee exercise program, Keep the Beat, on blood vessel function. Damage to blood vessels can cause narrowing of the vessels, resulting in reduced blo...
Detailed Description
Evidence suggests that Americans are becoming increasingly sedentary at work and at home due to technological advances. Physical inactivity coupled with excess caloric intake, especially of calorie-ri...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA:
- Employees of NHLBI who are not currently participating in the Keep the Beat program (this may include employees who have previously registered for Keep the Beat program, but who have not participated in the past 3 months) and NIH employees who can use the excercise rooms in Building 10, Building 31, or Rockledge II.
- No medical condition that might prohibit safe participation in the Keep the Beat program.
- Subject understands protocol and provides written, informed consent in addition to willingness to comply with specified follow-up evaluations.
- EXCLUSION CRITERIA:
- Heart disease as indicated by history of myocardial infarction, documented disease on coronary angiography, coronary artery stent placement, congestive heart failure, significant structural heart disease (e.g. hypertrophic or dilated cardiomyopathy, or valvular heart disease), or positive treadmill exercise test at baseline.
- Baseline blood pressure systolic greater than 140 mmHg or diastolic greater than 90 mmHg on 2 measures with or without hypertensive medications. Subjects will be encouraged to seek evaluation by their primary care provider.
- Baseline fasting blood glucose greater than 126 mg/dl, if subject previously undiagnosed as being diabetic. Subjects will be encouraged to seek evaluation by their primary care provider.
- Baseline fasting LDL greater than 190 mg/dl. Subjects will be encouraged to seek evaluation by their primary care provider.
- Physically unable to perform the Keep the Beat program due to neurologic or orthopedic conditions.
- Pregnant women will be excluded due to large hormonal changes in pregnancy that affect study variables and potential pregnancy-related restrictions on exercise.
- Subjects currently exercising more than 1.5 hours per week including brisk walking, sporting activities (such as basketball), and other deliberate exercise.
- Subjects may not be currently participating or participate over the course of the study in another study protocol which includes blood draws or interventions.
Exclusion
Key Trial Info
Start Date :
October 26 2005
Trial Type :
INTERVENTIONAL
End Date :
April 15 2009
Estimated Enrollment :
120 Patients enrolled
Trial Details
Trial ID
NCT00246883
Start Date
October 26 2005
End Date
April 15 2009
Last Update
July 2 2017
Active Locations (1)
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1
National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States, 20892