Status:
COMPLETED
Assessing Mucociliary Clearance and Airway Liquid Volume in the CF Airway
Lead Sponsor:
University of Pittsburgh
Collaborating Sponsors:
Cystic Fibrosis Foundation
Conditions:
Cystic Fibrosis
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The objective of this study is to determine the effect of airway surface liquid (ASL) volume on mucociliary clearance in cystic fibrosis (CF). A two-isotope nuclear medicine technique will be utilized...
Detailed Description
Improper function of the mucociliary clearance system in the Cystic Fibrosis (CF) lung is a major factor contributing to the chronic respiratory manifestations of the disease. Normally this host defen...
Eligibility Criteria
Inclusion
- Age ≥ 18 years
- Diagnosis of cystic fibrosis as determined by sweat test or genotype and clinical symptoms (CF subjects only)
- Clinically stable as determined by the investigator (pulmonologist)
Exclusion
- Reactive airways disease
- Tobacco smokers
- Positive urine pregnancy test on the day of testing
- FEV1p value of \< 30%
- SaO2 \< 92%, or if they require supplemental oxygen.
- Subjects receiving other radioisotope treatments within the last 2 weeks will be excluded.
- Normal subjects with any history of lung disease will be excluded.
- Women currently breastfeeding an infant.
Key Trial Info
Start Date :
November 1 2005
Trial Type :
INTERVENTIONAL
End Date :
August 1 2006
Estimated Enrollment :
14 Patients enrolled
Trial Details
Trial ID
NCT00248755
Start Date
November 1 2005
End Date
August 1 2006
Last Update
July 25 2017
Active Locations (1)
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1
University of Pittsburgh
Pittsburgh, Pennsylvania, United States, 15213