Status:
TERMINATED
Effectiveness of Sertraline in Treating Pathological Gamblers With a Diagnosis of Alcohol Dependence - 1
Lead Sponsor:
New York State Psychiatric Institute
Collaborating Sponsors:
National Institute on Drug Abuse (NIDA)
Conditions:
Alcoholism
Gambling
Eligibility:
All Genders
18-65 years
Phase:
PHASE2
Brief Summary
Pathological gamblers often are also dependent on alcohol and clinically depressed. Sertraline (Zoloft) is currently used to treat depression, panic disorder, and obsessive-compulsive disorder. The pu...
Detailed Description
Alcohol abuse and depression commonly occur in conjunction with pathological gambling. Sertraline (Zoloft) is a selective serotonin reuptake inhibitor (SSRI) currently used to treat depression, panic ...
Eligibility Criteria
Inclusion
- Meets DSM-IV criteria for pathological gambling
- Meets DSM-IV and SCID criteria for alcohol abuse or dependence
- Medically healthy
Exclusion
- History of schizophrenia, schizoaffective disorder, or bipolar disorder
- Current diagnosis of substance abuse or dependence, other than alcohol or nicotine
- Current major depression
- Currently suicidal
- History of non-response to an adequate trial of sertraline, defined as 200 mg per day of sertraline for at least a 4-week period
- Previous treatment with relapse prevention therapy for pathological gambling or alcohol dependence within the 3 months prior to study entry
- Requires treatment with psychotropic medication
- Unwilling to consent to a drug-free period, according to the following: 2 weeks of abstinence from antidepressant drugs, other than fluoxetine, buspirone, lithium, anticonvulsants, barbiturates, opiates, or benzodiazepines; 4 weeks of abstinence from clonazepam; 5 weeks of abstinence from fluoxetine
- Clinically significant disorder, including kidney, pulmonary, cerebral vascular, cardiovascular, gastrointestinal, and endocrine disorders
- Abnormal laboratory tests
- Abnormal electrocardiogram
- Pregnant or breastfeeding
- Unwilling to use an adequate method of contraception for the duration of the study
Key Trial Info
Start Date :
December 1 2001
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2005
Estimated Enrollment :
9 Patients enrolled
Trial Details
Trial ID
NCT00249431
Start Date
December 1 2001
End Date
December 1 2005
Last Update
October 27 2017
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