Status:
COMPLETED
Procalcitonin-Guided Antimicrobial Discontinuation
Lead Sponsor:
University Hospital, Geneva
Conditions:
Sepsis
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
The current study aims to validate the diagnostic use of PCT assessing its capability to individualize and shorten the duration of antibiotic therapy in critically ill patients with suspected or confi...
Detailed Description
Primary objective: To assess the effect of repeated PCT measurements in critically ill patients with clinically suspected or microbiologically documented sepsis on duration of antimicrobial use and t...
Eligibility Criteria
Inclusion
- Patients with clinically suspected or microbiologically confirmed bacterial sepsis
- Informed consent
Exclusion
- Patients with microbiologically documented infections caused by the following microorganisms: Listeria spp, Legionella pneumophilia, Mycobacterium tuberculosis, Staphylococcus aureus
- Patients with fungal infections
- Patients with severe infections due to viruses or parasites (e.g. hemorrhagic fever, malaria)
- Patients with suspected or confirmed bacterial meningitis or endocarditis
- Patients with localized, deep-seated abscesses (e.g. brain abscess) without systemic sepsis
- Patients with chronic, localized infections (e.g. chronic osteomyelitis) without systemic sepsis
- Neutropenic and other severely immuno-compromised patients (patients infected with human immunodeficiency virus and a CD4 count \< 200; patients on immuno-suppressive therapy after solid organ transplantation; patients with cystic fibrosis)
- Withholding of life-support
- Early discharge or death (\< 24 hours after admission)
- Complete absence of antimicrobial treatment despite suspicion of sepsis
Key Trial Info
Start Date :
January 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
May 1 2007
Estimated Enrollment :
70 Patients enrolled
Trial Details
Trial ID
NCT00250666
Start Date
January 1 2006
End Date
May 1 2007
Last Update
July 8 2008
Active Locations (1)
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1
Geneva Universits Hospitals
Geneva, Switzerland, 1211