Status:
COMPLETED
AutoVPAP Versus VPAP; Assessment of Sleep and Ventilation
Lead Sponsor:
ResMed
Collaborating Sponsors:
Royal Brompton & Harefield NHS Foundation Trust
Conditions:
Chest Wall Disorder
Neuromuscular Disease
Eligibility:
All Genders
18-80 years
Phase:
PHASE1
Brief Summary
The aim of the study is to compare the effects of a modified form (AutoVPAP) of the VPAP non-invasive ventilator versus standard VPAP ventilation on sleep quality and breathing during sleep in stable ...
Eligibility Criteria
Inclusion
- Patients aged 18-80 years
- Nocturnal hypoventilation (nocturnal peak transcutaneous PCO2 \> 6.5 kPa when breathing spontaneously) with
- Congenital neuromuscular disease (eg. Duchenne muscular dystrophy, congenital muscular dystrophy), acquired neuromuscular disease (eg. old polio, bilateral diaphragm paralysis) or chest wall disease (eg. idiopathic scoliosis, thoracoplasty)
- Recruited from 1300 patients attending Royal Brompton Hospital Lind ward ventilator clinic.
- All patients will be familiar with non-invasive ventilation use but currently using a ventilator which is not a VPAP model eg. BiPAP Harmony, Breas PV403.
- Able to understand treatment and protocol
Exclusion
- Unstable respiratory failure (PaO2 \< 7.5 kPa, PaCO2 \> 8.0 kPa,
- Uncontrolled heart failure or arrhythmia
- Moderate or severe bulbar weakness.
- Unable to understand treatment or protocol
Key Trial Info
Start Date :
November 1 2005
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2007
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT00252252
Start Date
November 1 2005
End Date
December 1 2007
Last Update
June 24 2008
Active Locations (1)
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1
Royal Brompton Hospital
London, Greater London, United Kingdom, SW3 6NP