Status:
COMPLETED
Danish Osteoporosis Prevention Study
Lead Sponsor:
University of Aarhus
Collaborating Sponsors:
Karen Elise Jensen Foundation
Novo Nordisk A/S
Conditions:
Osteoporosis
Eligibility:
FEMALE
45-58 years
Phase:
PHASE4
Brief Summary
Hypothesis: Use of hormone replacement therapy (HRT) decreases the incidence of fractures in early postmenopausal women. The project was initiated in 1990, and the inclusion ended in 1993. A total of...
Detailed Description
Aim: To study the ability of hormone replacement early after menopause on risk of fractures and changes in bone mineral density, and side effects. The project was designed as a comprehensive cohort t...
Eligibility Criteria
Inclusion
- Women aged 45-58 years with an intact uterus
- Three to 24 month past last menstrual bleeding
- Hysterectomised women aged 45-52 years and having elevated FSH
Exclusion
- Metaboliv bone disease including osteoporosis defined as non-traumatic vertebral fractures on X-ray
- Current estrogen use or estrogen use within the past three month
- Current or past treatment with glucocorticoids for more than 6 month
- Current or past malignancy
- Newly diagnosed or uncontrolled chronic disease
- Alcohol or drug addiction
Key Trial Info
Start Date :
October 1 1990
Trial Type :
INTERVENTIONAL
End Date :
December 1 2003
Estimated Enrollment :
2000 Patients enrolled
Trial Details
Trial ID
NCT00252408
Start Date
October 1 1990
End Date
December 1 2003
Last Update
September 4 2009
Active Locations (1)
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1
The Osteoporosis Clinic, Aarhus Sygehus
Aarhus, Denmark, DK-8000