Status:
COMPLETED
Cetuximab, Bevacizumab & 5FU/Leucovorin vs. Oxaliplatin, Bevacizumab & 5FU/Leucovorin in Metastatic Colorectal Cancer
Lead Sponsor:
US Oncology Research
Collaborating Sponsors:
Bristol-Myers Squibb
Memorial Sloan Kettering Cancer Center
Conditions:
Metastatic Colorectal Cancer
Eligibility:
All Genders
18+ years
Phase:
PHASE3
Brief Summary
The purpose of this study is to compare the rates of Progression-Free Survival (PFS) at 12 months for patients treated with Bev-FOLFOX versus patients treated with FOLF-CB for first line treatment of ...
Detailed Description
This is a Phase III, open label, nonblinded study. A total of 240 eligible patients will be randomized on a 1:1 basis to either treatment Arm. In this trial, we will compare the efficacy, safety, and...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA:
- Histologically or cytologically confirmed colorectal cancer with metastatic disease
- Measurable disease
- Previously irradiated lesions will be considered evaluable, if they progressed since radiation
- Has disease other than limited to surgically resectable liver-only or lung-only metastatic disease
- Not received prior chemo and/or biotherapy for metastatic disease
- Not received oxaliplatin, bevacizumab, or cetuximab in the adjuvant setting
- May have received 5-FU, leucovorin, and/or irinotecan in the adjuvant setting, however must have remained free of disease recurrence (including free of abnormal CEA level) for 1- year or more
- Is \>18 years of age
- ECOG performance status 0 or 1
- Normal organ \& marrow function
- Use of an acceptable method of birth control
- Not pregnant or breast feeding
- Paraffin tissue block(s) or 12 (minimum) unstained slides available, for assessment of potential predictive markers related to the EGFR, VEGF, DNA repair, and fluoropyrimidine catabolism pathways. If no block is available, slides (typically 7 to 10 um sections, air dried on uncharged slides) may be sent
- Signed a Patient Informed Consent Form
- Signed a Patient Authorization Form (HIPAA) Form
- EXCLUSION CRITERIA:
- Had prior chemotherapy for metastatic colorectal cancer
- Received any prior treatment with oxaliplatin, bevacizumab, or cetuximab in the adjuvant treatment of their colorectal cancer
- Currently receiving any other investigational anticancer agents or has participated in an experimental drug study within the past 4 weeks
- History of primary CNS tumors, seizures not well-controlled with standard medical therapy, or stroke
- Sustained hypertension, as characterized by persistent blood pressures greater than 150/100 despite medical management
- New York Heart Association (NYHA) Grade II or greater congestive heart failure or has had angioplasty or placement of coronary stents within the past 6 months
- Clinically significant peripheral vascular disease
- History of serious allergic reactions attributed to compounds of similar chemical or biologic composition to bevacizumab, cetuximab, oxaliplatin, fluorouracil, leucovorin, or other agents used in the study
- Received prior cetuximab or other EGFR-directed therapy, or history of prior anti-cancer murine or chimeric monoclonal antibody therapy; prior humanized and human monoclonal antibody therapy is also excluded.
- Received prior treatment with bevacizumab or other agents specifically targeting VEGF or VEGF receptors
- Uncontrolled intercurrent illness including, not limited to, ongoing or active infection requiring parenteral antibiotics, symptomatic congestive heart failure, uncontrolled hypertension, clinically significant cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements in the opinion of the Investigator/Treating Physician
- Serious or non-healing active wound ulcer, or active bone fracture
- Major surgical procedure, open biopsy, or significant traumatic injury within 28 days prior to Day 1 of protocol treatment
- Minor surgical procedures such as fine needle aspirations or core biopsies within 7 days prior to Day 1
- History of abdominal fistula, gastrointestinal perforation, or intra-abdominal abscess within 6 months prior to Day 1
- Current or recent use of a thrombolytic agent within last 30 days. Use for clearance of central line catheter is permitted.
- Evidence of bleeding diathesis (disorder) or clinically significant coagulopathy (Note that deep venous thrombosis is not regarded as a reason for exclusion from this trial)
- Hypersensitivity to Chinese hamster ovary cell products or other recombinant human antibodies
- History of arterial thromboembolic events within 6 months
- Urine protein:creatinine ratio greater than 1.0 at screening
- Pregnant or lactating woman
- Known to be HIV positive or receiving combination anti-retroviral therapy
- Unable to comply with study requirements
Exclusion
Key Trial Info
Start Date :
September 1 2005
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2009
Estimated Enrollment :
247 Patients enrolled
Trial Details
Trial ID
NCT00252564
Start Date
September 1 2005
End Date
June 1 2009
Last Update
February 15 2019
Active Locations (82)
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1
Brimingham Hematology and Oncology
Birmingham, Alabama, United States, 35235
2
Hematology Oncology Associates
Phoenix, Arizona, United States, 85012
3
Northern AZ Hematology & Oncology Assoc
Sedona, Arizona, United States, 86336
4
Business Office - ACRC
Tucson, Arizona, United States, 85715