Status:
UNKNOWN
Alterations in Protein Synthesis Rates of Burn Patients Measured Over Time Using PET Scans
Lead Sponsor:
Massachusetts General Hospital
Collaborating Sponsors:
National Institute of General Medical Sciences (NIGMS)
Conditions:
Burn
Eligibility:
All Genders
18-70 years
Brief Summary
Our specific aim is to gain an understanding of protein synthesis rates in burn patients at various times during their injury and recovery by using PET scans. This will be compared with healthy volunt...
Detailed Description
The purpose of this study is to understand how muscles are built up and broken down (metabolism) in both burn patients and healthy people.The studies will help us understand how muscle metabolism is d...
Eligibility Criteria
Inclusion
- FOR HEALTHY VOLUNTEERS
- Healthy males and females 18-70 years of age.
- Laboratory results within MGH-accepted normal range.
- Within 20% of the ideal weight for their height.
- Supine and standing blood pressure within the range of 110/60 to 150/90 mm Hg
- Heart rate within the range of 46-90 beats/minute after 5 minutes of rest.
- Subjects \<40 years old with HCT \>=24, age 40-60 with HCT \>=27, age 60-70 with HCT \>=30.
- FOR BURN SUBJECTS:
- Burn Injury of \>=5 % TBSA from any cause.
- 18 -70 years of age
- Stable hemodynamic and cardiopulmonary states as judged by the attending surgeons in the burn unit.
- Patient who is capable of giving full informed consent.
Exclusion
- FOR HEALTHY SUBJECTS Clinical evidence of physical or mental disease.
- Clinically significant abnormality of the laboratory tests.
- Known drug or alcohol dependence.
- History of drug allergy
- Taking standard prescription drugs within two weeks or investigational drugs within four weeks prior to the PET scan
- Diabetes mellitus and other metabolic endocrine disorders Pregnant or lactating
- FOR BURN SUBJECTS:
- Pregnant or lactating females
Key Trial Info
Start Date :
November 1 2009
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
January 1 2010
Estimated Enrollment :
64 Patients enrolled
Trial Details
Trial ID
NCT00253279
Start Date
November 1 2009
End Date
January 1 2010
Last Update
August 13 2009
Active Locations (1)
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1
Massachusetts General Hospital
Boston, Massachusetts, United States, 02114