Status:
COMPLETED
The Role of Cytokine-Serotonin Interactions in Post-Stroke Depression
Lead Sponsor:
Sunnybrook Health Sciences Centre
Conditions:
Depression
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
Depression is a common and often serious problem occurring in stroke patients. Inflammatory hormones, known as cytokines, are stimulated by an activated immune system and sometimes become active follo...
Eligibility Criteria
Inclusion
- Age \> 18 years
- Gender: male or female
- Language: speaks and understands English
- Clinical diagnosis of stroke according to World Health Organization MONICA Project and recent (\< 3 months) cerebral infarctions
- Written, informed consent
- Depressed group only: diagnosis of a major depressive episode according to the depression module of the Structured Clinical Interview for the DSM-IV (SCID-IV)
Exclusion
- Subarachnoid hemorrhage
- Intracranial hemorrhage
- Significant acute medical illness including: drug overdose, severely disturbed liver, kidney or lung function, anemia, hypothyroidism, or uncontrolled diabetes
- Significant acute neurologic illness including: impaired consciousness, Parkinson's disease, Huntington's chorea, progressive supranuclear paralysis, brain tumor, subdural hematoma, multiple sclerosis, hydrocephalus, Binswanger's disease, or severe aphasia
- Presence of a premorbid Axis I psychiatric diagnosis (eg. schizophrenia, bipolar disorder)
- Depressed group only: contraindications to receiving treatment with citalopram (including previous nonresponse) or serious risk of suicide
Key Trial Info
Start Date :
June 1 2005
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2013
Estimated Enrollment :
138 Patients enrolled
Trial Details
Trial ID
NCT00254020
Start Date
June 1 2005
End Date
December 1 2013
Last Update
April 28 2017
Active Locations (5)
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1
York Central Hospital
Richmond Hill, Ontario, Canada, L4C 4Z3
2
St. John's Rehabilitation Hospital
Toronto, Ontario, Canada, M2M 2G1
3
Toronto Rehabilitation Institute
Toronto, Ontario, Canada, M4G 1R7
4
Sunnybrook Health Sciences Centre
Toronto, Ontario, Canada, M4N 3M5