Status:
COMPLETED
DHEA and Testosterone Replacement in Elderly
Lead Sponsor:
Mayo Clinic
Collaborating Sponsors:
National Institute on Aging (NIA)
National Institutes of Health (NIH)
Conditions:
Aging
Low DHEA for Women
Eligibility:
All Genders
60+ years
Phase:
NA
Brief Summary
Sarcopenia is a major health problem among the rapidly expanding elderly population in our society. Disabilities directly related to muscle weakness, and indirectly related to changes in body composit...
Eligibility Criteria
Inclusion
- Inclusion criteria:
- bioavailable testosterone less than 103 nanogram/dl and DHEA-S level less than 157 microgram/dl for men; DHEA-S less than 95 microgram/dl for women;
- Exclusion criteria:
- significant ischemic heart disease, renal disease, uncontrolled hypertension, diabetes mellitus, malignancy, malabsorption, bone disorders, chronic obstructive pulmonary disease, or sleep apnea.
- Others exclusion criteria include abnormal serum calcium, phosphorus, alkaline phosphatase, asparate aminotransferase, creatinine, urinary calcium, thyroid stimulating hormone, and erythrocyte sedimentation rate.
- People taking medication that may affect outcome measures such as adrenal steroids, anticonvulsant therapy thiazide diuretics, and estrogen replacement were also excluded. People engaged in a regular exercise program lasting more than 20 minutes more than two times per week and those men whose PSA level (age adjusted upper limit) were also excluded.
Exclusion
Key Trial Info
Start Date :
July 1 1998
Trial Type :
INTERVENTIONAL
End Date :
February 1 2007
Estimated Enrollment :
150 Patients enrolled
Trial Details
Trial ID
NCT00254371
Start Date
July 1 1998
End Date
February 1 2007
Last Update
May 23 2011
Active Locations (1)
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1
Mayo Clinic
Rochester, Minnesota, United States, 55905