Status:
COMPLETED
Effects of Smoked Marijuana on Neuropathic Pain
Lead Sponsor:
Center for Medicinal Cannabis Research
Conditions:
Neuropathic Pain
Eligibility:
All Genders
18-70 years
Phase:
PHASE1
PHASE2
Brief Summary
To determine if smoking marijuana will reduce neuropathic pain without causing too much drowsiness or feeling "too dopey".
Detailed Description
The case for marijuana's medical use for pain is primarily from experimental studies with normal subjects, which have yielded conflicting results. Experimental subjects have been shown to have signifi...
Eligibility Criteria
Inclusion
- Able to understand English
- Age greater than 18 and less than 70
- VAS greater than 3/10
- History of previous marijuana use (i.e., avoidance of marijuana naive subjects)
- Negative urine drug screening test
- Nerve Injury a.k.a. Complex Regional Pain Syndrome Type II OR
- Complex Regional Pain Syndrome Type I OR
- Neuropathic pain due to confirmed bilateral distal peripheral neuropathy associated with Diabetes I or II, focal nerve injury, postherpetic neuralgia, spinal cord injury with incomplete myelopathy, central pain following a stroke or focal brain lesion, or clinical definite multiple sclerosis of at least 3 months duration.
Exclusion
- Presence of another painful condition of greater severity than the neuropathic pain condition which is being studied
- Unstable Type 1 or 2 diabetes defined as blood glucose more than 156 mg/dl
- For diabetic subjects maintained on insulin with a stable blood glucose more than 156 mg/dl, a hemoglobin A1C level of more than 0.11 (normal range, 0.048-0.067)
- History of traumatic brain injury
- History of schizophrenia or a past or current history of a serious psychiatric disorder that is currently not well controlled with medications
- Uncontrolled medical condition - coronary artery disease, hypertension, cerebrovascular disease, asthma, TB, COPD, opportunistic infection, malignancy requiring active treatment
- Active substance abuse (alcohol or injection drugs)
- Current use of marijuana (within 30 days of randomization) as determined by urine screening
Key Trial Info
Start Date :
November 1 2003
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 1 2006
Estimated Enrollment :
28 Patients enrolled
Trial Details
Trial ID
NCT00254761
Start Date
November 1 2003
End Date
February 1 2006
Last Update
February 28 2008
Active Locations (1)
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1
UC Davis Medical Center
Sacramento, California, United States, 95817