Status:
COMPLETED
Psychiatric Correlates of Psychogenic Movement Disorder and Non-Epileptic Seizure
Lead Sponsor:
National Institute of Neurological Disorders and Stroke (NINDS)
Conditions:
Psychogenic Movement Disorders
Non-epileptic Seizures
Eligibility:
All Genders
18+ years
Brief Summary
This study will explore how the mind and the brain work to cause movement symptoms or seizures in people who do not have a recognized neurological or medical disorder. The study includes a check for p...
Detailed Description
Objectives The objectives of this study are (1) to investigate the relationship between childhood abuse and dissociative experiences in both psychogenic movement disorders (PMD) and non-epileptic sei...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA:
- Patients for dissociation study:
- Diagnosis of clinically definite PMD utilizing Fahn and Williams criteria. The diagnosis will be made by a movement disorders neurologist.
- Or a diagnosis of NES based on video-EEG. The diagnosis will be made by an epileptologist.
- Males or females
- Age 18 or older
- Able to provide informed consent
- Patients for cognitive study:
- Diagnosis of clinically definite PMD utilizing Fahn and Williams criteria. The diagnosis will be made by a movement disorders neurologist.
- Age 18 or older
- Males or females
- Able to provide informed consent
- Normal volunteers for cognitive study:
- Normal volunteers age 18 or older will be included
- Males or females
- Able to provide informed consent
- EXCLUSION CRITERIA:
- Patients for dissociation study:
- Diagnosis of probable or possible PMD using Fahn and Williams criteria.
- Patients with neurological disorders with elaboration of their underlying disease process including comorbid epilepsy.
- Patients with a medical condition that prevents them from taking part in the study.
- Patients with current suicidal ideation.
- Patients with a psychotic disorder.
- Patients with active substance abuse within the last 6 months.
- Patients below the age of 18.
- Patients who are not capable of consent.
- Patients with an IQ less than 55.
- Patients currently involved in lawsuits.
- Patients for cognitive study:
- Diagnosis of probable or possible PMD using Fahn and Williams criteria
- Patients with neurological disorders with elaboration of their underlying disease process including comorbid epilepsy
- Patients with a medical condition that prevents them from taking part in the study.
- Patients with a history of a neurological disorder (e.g. dementia, cerebrovascular accident, neurodegenerative disorder, inflammatory disorders or infections of the central nervous system) that may result in cognitive deficits.
- Patients with a history of traumatic brain injury resulting in loss of consciousness or amnesia lasting for more than a few seconds.
- Patients with a psychotic disorder or bipolar disorder
- Patients with a current major depression
- Patients with current moderate to severe anxiety (Hamilton Anxiety Rating Scale greater than 25)
- Patients with current attention deficit hyperactivity disorder.
- Patients with active substance abuse within the last 6 months.
- Patient with current suicidal ideation.
- Patients below the age of 18.
- Patients who are not capable of consent.
- Patients with an IQ less than 55.
- Patients currently involved in lawsuits.
- Normal volunteers for cognitive study:
- Normal volunteers younger than 18 years
- Normal volunteers with an active medical condition that might prevent participation.
- Normal volunteers with a history of neurological disorders (e.g. dementia, cerebrovascular accident, neurodegenerative disorder, inflammatory disorders or infections of the central nervous system) that may result in cognitive deficits
- Normal volunteers with a history of traumatic brain injury resulting in loss of consciousness or amnesia lasting for more than a few seconds
- Normal volunteers with a psychotic disorder or bipolar disorder
- Normal volunteers with a current major depression
- Normal volunteers with moderate to severe anxiety (Hamilton Anxiety Rating Scale greater than 25)
- Normal volunteers with active substance abuse within the last 6 months
- Normal volunteers with current attention deficit hyperactivity disorder
- Normal volunteers with an IQ less than 55
- Normal volunteers who are not capable of consent
Exclusion
Key Trial Info
Start Date :
November 9 2005
Trial Type :
OBSERVATIONAL
End Date :
February 24 2009
Estimated Enrollment :
190 Patients enrolled
Trial Details
Trial ID
NCT00255411
Start Date
November 9 2005
End Date
February 24 2009
Last Update
July 2 2017
Active Locations (1)
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1
National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States, 20892